AS-041164

Modify Date: 2024-01-03 22:46:45

AS-041164 Structure
AS-041164 structure
 Common Name AS-041164
CAS Number 6318-41-8 Molecular Weight 249.243
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C11H7NO4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AS-041164


AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects[1].

 Names

Name 5-(1,3-benzodioxol-5-ylmethylidene)-1,3-thiazolidine-2,4-dione
Synonym More Synonyms

 AS-041164 Biological Activity

Description AS-041164 is a potent, selective and orally active PI3Kγ isoform inhibitor with an IC50 of 70 nM. AS-041164 shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). AS-041164 has anti-inflammatory effects[1].
Related Catalog
Target

PI3Kγ:70 nM (IC50)

PI3Kα:240 nM (IC50)

PI3Kβ:1.4 μM (IC50)

PI3Kδ:1.7 μM (IC50)

In Vivo AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema[1]. AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation[1]. Animal Model: Male Wistar rats (100-150 g) injected with carrageenan[1] Dosage: 10 mg/kg, 30 mg/kg, 100 mg/kg Administration: Oral administration; once Result: Induced a significant reduction of paw thickness.
References

[1]. Chiara Ferrandi, et al. Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment. J Pharmacol Exp Ther. 2007 Sep;322(3):923-30.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C11H7NO4S
Molecular Weight 249.243
Exact Mass 249.009583
PSA 89.93000
LogP 2.46
Index of Refraction 1.731

 Synthetic Route

2,4-Thiazolidinedione structure

2,4-Thiazolidin...

CAS#:2295-31-0

piperonal structure

piperonal

CAS#:120-57-0

~%

AS-041164 Structure

AS-041164

CAS#:6318-41-8

Literature: Kucera Monatshefte fuer Chemie, 1914 , vol. 35, p. 142

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

2,5-Thiazolidinedione, 4-(1,3-benzodioxol-5-ylmethylene)-, (4E)-
5-Piperonyliden-2,4-thiazolidindion
(4E)-4-(1,3-Benzodioxol-5-ylmethylene)-1,3-thiazolidine-2,5-dione
5-piperonylidene-thiazolidine-2,4-dione
5-Piperonyliden-thiazolidin-2,4-dion
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Chemsrc provides AS-041164(CAS#:6318-41-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of AS-041164 are included as well.>> amp version: AS-041164

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