Mosapride citrate
Modify Date: 2024-01-02 21:04:25
Mosapride citrate structure
|
Common Name | Mosapride citrate | ||
|---|---|---|---|---|
| CAS Number | 636582-62-2 | Molecular Weight | 538.00800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H33ClFN3O6 | Melting Point | 112-114°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05 |
Signal Word | Danger | |
Use of Mosapride citrateMosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with 5-hydroxytryptamine4 receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibits Kv4.3 in a concentration-dependent manner with IC50 values of 15.2 μM[1]. Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo[2]. |
| Name | Mosapride Citrate Dihydrate |
|---|---|
| Synonym | More Synonyms |
| Description | Mosapride (TAK-370) citrate dehydrate is a gastroprokinetic agent with 5-hydroxytryptamine4 receptor agonist activity and has been widely used in the research of a variety of gastrointestinal disorders. Mosapride citrate dihydrate potently inhibits Kv4.3 in a concentration-dependent manner with IC50 values of 15.2 μM[1]. Mosapride citrate dihydrateselectively stimulates upper GI motility in vivo[2]. |
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| Related Catalog | |
| Target |
5-HT4 Receptor Kv4.3:15.2 μM (IC50) |
| In Vitro | Mosapride (0.3-30 μM) exhibits an inhibitory activity against Kv4.3 with an IC50 of 15.2 μM in a concentration-dependent manner. Mosapride also inhibits the open state of Kv4.3 currents during depolarization and accelerates the closed-state inactivation at subthreshold potentials[1]. |
| In Vivo | Mosapride (Intravenous injection;0.3-3 mg/kg) dose-dependently increases the antral motor activity in conscious dogs which indicates that mosapride selectively stimulates upper gastrointestinal motility[2]. Animal Model: Beagle dogs[2] Dosage: 0.3-3 mg/kg Administration: Intravenous injection; 0.3-3 mg/kg Result: Increased the antral motor activity dose-dependently in conscious dogs. |
| References |
| Melting Point | 112-114°C |
|---|---|
| Molecular Formula | C26H33ClFN3O6 |
| Molecular Weight | 538.00800 |
| Exact Mass | 537.20400 |
| PSA | 134.68000 |
| LogP | 4.62490 |
| Storage condition | 2-8°C |
| 5-Oxopentanoic acid - 4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobe nzyl)-2-morpholinyl]methyl}benzamide (1:1) |