FF-MAS

Modify Date: 2024-01-14 21:40:21

FF-MAS Structure
FF-MAS structure
Common Name FF-MAS
CAS Number 64284-64-6 Molecular Weight 410.67500
Density 1g/cm3 Boiling Point 512.6ºC at 760 mmHg
Molecular Formula C29H46O Melting Point N/A
MSDS N/A Flash Point 221.9ºC

 Use of FF-MAS


FF-MAS is a potent meiotic maturation agonist. FF-MAS promotes meiotic maturation and preimplantation development of mouse oocytes maturing in vitro. FF-MAS promotes the completion of meiotic maturation to metaphase II (MII) and improves competence to complete the 2-cell stage to blastocyst transition[1][2].

 Names

Name 4,4-dimethyl-5α-cholesta-8,14,24-trien-3β-ol
Synonym More Synonyms

 FF-MAS Biological Activity

Description FF-MAS is a potent meiotic maturation agonist. FF-MAS promotes meiotic maturation and preimplantation development of mouse oocytes maturing in vitro. FF-MAS promotes the completion of meiotic maturation to metaphase II (MII) and improves competence to complete the 2-cell stage to blastocyst transition[1][2].
Related Catalog
In Vitro FF-MAS (1 µM;16-17 小时) 促进减数分裂成熟的完成和卵母细胞完成从 2 细胞阶段到囊胚转变的能力[1]。
References

[1]. Marín Bivens CL, et al. A synthetic analogue of meiosis-activating sterol (FF-MAS) is a potent agonist promoting meiotic maturation and preimplantation development of mouse oocytes maturing in vitro. Hum Reprod. 2004 Oct;19(10):2340-4.  

[2]. Thorsten Blume, et al. Two Syntheses of FF-MAS. Org. Lett. 2003, 5, 11, 1837-1839.

 Chemical & Physical Properties

Density 1g/cm3
Boiling Point 512.6ºC at 760 mmHg
Molecular Formula C29H46O
Molecular Weight 410.67500
Flash Point 221.9ºC
Exact Mass 410.35500
PSA 20.23000
LogP 8.00910
Index of Refraction 1.541

 Synthetic Route

 Synonyms

(3R,5S,10S,13S,17S)-4,4,10,13-tetramethyl-17-[(2R)-6-methylhept-5-en-2-yl]-1,2,3,5,6,7,11,12,16,17-decahydrocyclopenta[a]phenanthren-3-ol
(3β,5α)-4,4-Dimethylcholesta-8,14,24-trien-3-ol
4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol