Lisofylline

Modify Date: 2025-08-22 14:40:13

Lisofylline Structure
Lisofylline structure
Common Name Lisofylline
CAS Number 6493-06-7 Molecular Weight 280.323
Density 1.3±0.1 g/cm3 Boiling Point 511.2±56.0 °C at 760 mmHg
Molecular Formula C13H20N4O3 Melting Point 123-125ºC
MSDS Chinese USA Flash Point 263.0±31.8 °C

 Use of Lisofylline


(±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research[1].

 Names

Name (±)-Lisofylline
Synonym More Synonyms

 Lisofylline Biological Activity

Description (±)-Lisofylline ((±)-Lisophylline) is the racemate of Lisofylline. Lisofylline inhibits the generation of phosphatidic acid and free fatty acids. Lisofylline also blocks the release of pro-inflammatory cytokines in oxidative tissue injury, in response to cancer chemotherapy and in experimental sepsis. Lisofylline can be used for Type 1 diabetes research[1].
Related Catalog
References

[1]. Yang Z, et al. Lisofylline: a potential lead for the treatment of diabetes. Biochem Pharmacol. 2005 Jan 1;69(1):1-5.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 511.2±56.0 °C at 760 mmHg
Melting Point 123-125ºC
Molecular Formula C13H20N4O3
Molecular Weight 280.323
Flash Point 263.0±31.8 °C
Exact Mass 280.153534
PSA 82.05000
LogP 0.34
Appearance of Characters solid | white
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.621
Storage condition Refrigerator
Water Solubility DMSO: soluble

 Safety Information

RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

~91%

Lisofylline Structure

Lisofylline

CAS#:6493-06-7

Literature: Kala, Elzbieta P.; Wojcik, Tomasz Acta Poloniae Pharmaceutica - Drug Research, 2007 , vol. 64, # 2 p. 109 - 113

 Precursor & DownStream

Precursor  1

DownStream  0

 Articles1

More Articles
Calcitonin gene-related peptide inhibits human immunodeficiency type 1 transmission by Langerhans cells via an autocrine/paracrine feedback mechanism.

Acta Physiol. (Oxf.) 213(2) , 432-41, (2015)

Peripheral neurones innervating mucosal epithelia are in direct contact with resident immune cells, including Langerhans cells (LCs). Such neurones secrete the neuropeptide calcitonin gene-related pep...

 Synonyms

R-1-(5-Hydroxyhexyl)-3,7-dimethylxanthine
(R)-3,7-Dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-1H-purine-2,6-dione
1-[(5R)-5-Hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Penthydroxifillyne
HYDROXY PENTOXIFYLLINE
Lisofylline
1-(5-Hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione
1H-Purine-2,6-dione, 3,7-dihydro-1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-
UNII:R99EE080JS
1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-
ProTec
1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-, (R)-
1-[(R)-5-Hydroxyhexyl]theobromine
CT 1501R
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.