diosbulbin d

Modify Date: 2024-01-09 18:20:04

diosbulbin d Structure
diosbulbin d structure
Common Name diosbulbin d
CAS Number 66756-57-8 Molecular Weight 344.36
Density 1.3±0.1 g/cm3 Boiling Point 599.1±50.0 °C at 760 mmHg
Molecular Formula C19H20O6 Melting Point N/A
MSDS N/A Flash Point 316.2±30.1 °C

 Use of diosbulbin d


Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells[1].

 Names

Name 2-(furan-3-yl)-11b-methyloctahydro-2h-7,10-methanooxepino[4,5-f]isochromene-4,6,8(1h)-trione
Synonym More Synonyms

 diosbulbin d Biological Activity

Description Diosbulbin D is a potential hepatotoxic compound that can be isolated from Dioscorea bulbifera L.. Diosbulbin D induces apoptosis in L-02 cells[1].
Related Catalog
In Vitro Diosbulbin D (10-80 μM; 12-72 h) 可诱导人正常肝脏 L-02 细胞毒性[1]。 Diosbulbin D (40 μM; 24 h) 诱导 L-02 细胞形态改变[1]。 Diosbulbin D (20-80 μM; 12-48 h) 诱导 L-02 细胞凋亡,并呈时间和浓度依赖性[1]。 Diosbulbin D (20-80 μM; 24 h) 诱导 L-02 细胞 caspase 3 的激活[1]。 Cell Viability Assay[1] Cell Line: L-02 cells Concentration: 10, 20, 40 and 80 μM Incubation Time: 12, 24, 48 and 72 h Result: Decreased L-02 cells viability in a concentration- and time-dependent manner. Apoptosis Analysis[1] Cell Line: L-02 cells Concentration: 20, 40 and 80 μM Incubation Time: 12, 24 and 48 h Result: Induced apoptosis in a time- and concentration-dependent manner.
References

[1]. Ma M, et al. The furano norclerodane diterpenoid disobulbin-D induces apoptosis in normal human liver L-02 cells. Exp Toxicol Pathol. 2012 Sep;64(6):611-8.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 599.1±50.0 °C at 760 mmHg
Molecular Formula C19H20O6
Molecular Weight 344.36
Flash Point 316.2±30.1 °C
Exact Mass 344.125977
PSA 82.81000
LogP -0.35
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.556

 Safety Information

Hazard Codes Xi

 Synonyms

(1S,2S,5S,8S,10R,11R,13S)-8-(3-Furyl)-10-methyl-7,14-dioxatetracyclo[11.2.1.0.0]hexadecane-3,6,15-trione
7,10-Methano-2H-pyrano[4,3-g][3]benzoxepin-4,6,8(1H)-trione, 2-(3-furanyl)octahydro-11b-methyl-, (2S,4aS,6aS,7S,10S,11aR,11bR)-
7,10-Methano-2H-pyrano[4,3-g][3]benzoxepin-4,6,8(1H)-trione, 2-(3-furanyl)octahydro-11b-methyl-
8-(3-Furyl)-10-methyl-7,14-dioxatetracyclo[11.2.1.0.0]hexadecane-3,6,15-trione
diosbulbin-d