Furazolidone
Furazolidone structure
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Common Name | Furazolidone | ||
|---|---|---|---|---|
| CAS Number | 67-45-8 | Molecular Weight | 225.158 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 353.4±52.0 °C at 760 mmHg | |
| Molecular Formula | C8H7N3O5 | Melting Point | 254-256ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 167.5±30.7 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
Use of FurazolidoneFurazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | furazolidone |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.Target: Antibacterial Furazolidone is a novel therapeutic strategy in AML patients. Furazolidone can Inhibit the bone-marrow transformation mediated by a series of leukemia fusion proteins. Furazolidone significantly inhibits proliferation of AML cell lines. Furazolidone induces apoptosis of the AML leukemic cells treatment with Furazolidone induces differentiation of AML cell lines. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 353.4±52.0 °C at 760 mmHg |
| Melting Point | 254-256ºC (dec.) |
| Molecular Formula | C8H7N3O5 |
| Molecular Weight | 225.158 |
| Flash Point | 167.5±30.7 °C |
| Exact Mass | 225.038574 |
| PSA | 100.86000 |
| LogP | -0.49 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.670 |
| InChIKey | PLHJDBGFXBMTGZ-UITAMQMPSA-N |
| SMILES | O=C1OCCN1N=Cc1ccc([N+](=O)[O-])o1 |
| Storage condition | 0-6°C |
| Water Solubility | formic acid: soluble50mg/mL |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H361 |
| Precautionary Statements | P281 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R62 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | RQ3675000 |
| HS Code | 2934992000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Furazolidone CAS#:67-45-8 |
| Literature: Journal of the American Chemical Society, , vol. 77, p. 2282 |
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Furazolidone CAS#:67-45-8 |
| Literature: Journal of the American Chemical Society, , vol. 77, p. 2282 |
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Furazolidone CAS#:67-45-8 |
| Literature: Journal of the American Chemical Society, , vol. 77, p. 2277,2280, 2281 |
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Furazolidone CAS#:67-45-8 |
| Literature: Journal of the American Chemical Society, , vol. 77, p. 2277,2280, 2281 |
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Furazolidone CAS#:67-45-8 |
| Literature: Journal of the American Chemical Society, , vol. 77, p. 2277,2280, 2281 |
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Furazolidone CAS#:67-45-8 |
| Literature: Industrial and Engineering Chemistry, , vol. 47, p. 358,359 Przemysl Chemiczny, , vol. 36, p. 400 Chem.Abstr., , p. 3140 |
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Furazolidone CAS#:67-45-8 |
| Literature: US2898335 , ; |
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Furazolidone CAS#:67-45-8 |
| Literature: US2742462 , ; |
![3-Oxazolidinamine,2-imino-N-[(5-nitro-2-furanyl)methylene] structure](https://image.chemsrc.com/caspic/498/5407-76-1.png)
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 3 | |
![3-[(5-aminofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one structure](https://image.chemsrc.com/caspic/039/13641-84-4.png)
CAS#:13641-84-4![N-[5-[[(2-oxo-1,3-oxazolidin-3-yl)amino]methylidene]furan-2-ylidene]acetamide structure](https://image.chemsrc.com/caspic/071/83796-92-3.png)
CAS#:83796-92-3
CAS#:69094-15-1This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934992000 |
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This table lists relevant public references with title, journal and publication metadata for this compound.
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Beneficial effects of intramyocardial mesenchymal stem cells and VEGF165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy.
J. Cell. Mol. Med. 19 , 1868-76, (2015) To explore the impact of myocardial injection of mesenchymal stem cells (MSCs) and specific recombinant human VEGF165 (hVEGF165 ) plasmid on collagen remodelling in rats with furazolidone induced dila... |
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Novel UV-spectrophotometric method for quantitative estimation of furazolidone using mixed hydrotropic agent.
Pak. J. Pharm. Sci. 26(1) , 159-62, (2013) A novel, eco friendly, accurate, sensitive, economic and safe spectrophotometric method was developed by application of mixed hydrotropy using 2 M sodium acetate, 8 M urea, 2 M niacinamide and 2 M sod... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273
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Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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Name: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
Source: NCGC
Target: N/A
External Id: SMAD3201
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Name: uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
Source: Burnham Center for Chemical Genomics
Target: cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id: SBCCG-A764-CF-PAF-Primary-Assay
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ant...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_ANT_FLUO8_1536_1X%INH PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Furall |
| Bifuron |
| MFCD00010550 |
| 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone |
| 3-{(E)-[(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one |
| 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone |
| Furidon |
| Furazolidone |
| 3-{[(E)-(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one |
| Neftin |
| nf-180 |
| Furazon |
| Furazol |
| Furaxon |
| Furox |
| 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone |
| EINECS 200-653-3 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of furazolidone? |
| A: Melting point of furazolidone is 254-256ºC (dec.). |
| Q: What are the storage conditions for furazolidone? |
| A: Storage conditions for furazolidone: 0-6°C. |
| Q: How is the water solubility of furazolidone? |
| A: Water solubility of furazolidone: formic acid: soluble50mg/mL. |
| Q: What are the upstream materials of furazolidone? |
| A: Related upstream materials(CAS) of furazolidone: 5407-76-1;405-22-1;80-65-9;698-63-5;75-44-5;28127-20-0;109-84-2;105-58-8;92-55-7;6270-33-3. |
| Q: What is the InChIKey of furazolidone? |
| A: InChIKey of furazolidone is PLHJDBGFXBMTGZ-UITAMQMPSA-N. |
| Q: What is the SMILES notation of furazolidone? |
| A: SMILES notation of furazolidone is O=C1OCCN1N=Cc1ccc([N+](=O)[O-])o1. |
| Q: What is the safety information for furazolidone? |
| A: Safety information for furazolidone: S36. |
| Q: What English synonyms does furazolidone have? |
| A: English synonyms of furazolidone: Furall, Bifuron, MFCD00010550, 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone, 3-{(E)-[(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one, 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone, Furidon, Furazolidone, 3-{[(E)-(5-Nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one, Neftin, nf-180, Furazon, Furazol, Furaxon, Furox, 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone, EINECS 200-653-3. |
| Q: What is the polar surface area (PSA) of furazolidone? |
| A: Polar surface area (PSA) of furazolidone is 100.86000. |
| Q: What is the molecular formula of furazolidone? |
| A: Molecular formula of furazolidone is C8H7N3O5. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |