Furazolidone
Furazolidone structure
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Common Name | Furazolidone | ||
|---|---|---|---|---|
| CAS Number | 67-45-8 | Molecular Weight | 225.158 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 353.4±52.0 °C at 760 mmHg | |
| Molecular Formula | C8H7N3O5 | Melting Point | 254-256ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 167.5±30.7 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Beneficial effects of intramyocardial mesenchymal stem cells and VEGF165 plasmid injection in rats with furazolidone induced dilated cardiomyopathy.
J. Cell. Mol. Med. 19 , 1868-76, (2015) To explore the impact of myocardial injection of mesenchymal stem cells (MSCs) and specific recombinant human VEGF165 (hVEGF165 ) plasmid on collagen remodelling in rats with furazolidone induced dilated cardiomyopathy (DCM). DCM was induced by furazolidone (... |
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Novel UV-spectrophotometric method for quantitative estimation of furazolidone using mixed hydrotropic agent.
Pak. J. Pharm. Sci. 26(1) , 159-62, (2013) A novel, eco friendly, accurate, sensitive, economic and safe spectrophotometric method was developed by application of mixed hydrotropy using 2 M sodium acetate, 8 M urea, 2 M niacinamide and 2 M sodium benzoate solution (25:25:25:25% V/V) as hydrotropic age... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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Developing structure-activity relationships for the prediction of hepatotoxicity.
Chem. Res. Toxicol. 23 , 1215-22, (2010) Drug-induced liver injury is a major issue of concern and has led to the withdrawal of a significant number of marketed drugs. An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification o... |
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A predictive ligand-based Bayesian model for human drug-induced liver injury.
Drug Metab. Dispos. 38 , 2302-8, (2010) Drug-induced liver injury (DILI) is one of the most important reasons for drug development failure at both preapproval and postapproval stages. There has been increased interest in developing predictive in vivo, in vitro, and in silico models to identify comp... |
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Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis.
Antimicrob. Agents Chemother. 51 , 1380-5, (2007) Screening for new antimicrobial agents is routinely conducted only against actively replicating bacteria. However, it is now widely accepted that a physiological state of nonreplicating persistence (NRP) is responsible for antimicrobial tolerance in many bact... |
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Furazolidone induces apoptosis through activating reactive oxygen species-dependent mitochondrial signaling pathway and suppressing PI3K/Akt signaling pathway in HepG2 cells.
Food Chem. Toxicol. 75 , 173-86, (2015) Furazolidone (FZD), a synthetic nitrofuran with a broad spectrum of antimicrobial activities, has been shown to be genotoxic and potentially carcinogenic in several types of cells. However, the proper molecular mechanisms of FZD toxicity remain unclear. This ... |
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Occurrence and distribution of sulfonamides, tetracyclines, quinolones, macrolides, and nitrofurans in livestock manure and amended soils of Northern China.
Environ. Sci. Pollut. Res. Int. 22(6) , 4545-54, (2015) A feasible and rapid analysis for the simultaneous determination of sulfonamides (SAs), tetracyclines (TCs), fluoroquinolones (FQs), macrolides (MACs) and nitrofurans (NFs) in livestock manure and soils was established by solid-phase extraction (SPE)-ultra-pe... |
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Analyses of enrofloxacin, furazolidone and malachite green in fish products with surface-enhanced Raman spectroscopy.
Food Chem. 135(2) , 845-50, (2012) Illegal fish drugs used in aquaculture have raised serious concerns due to their negative effects on public health and environment. In this study, surface-enhanced Raman spectroscopy (SERS) was applied to analyze prohibited aquaculture drugs including enroflo... |