Vitamin B12
Vitamin B12 structure
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Common Name | Vitamin B12 | ||
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| CAS Number | 68-19-9 | Molecular Weight | 1355.365 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C63H88CoN14O14P | Melting Point | >300ºC | |
| MSDS | Chinese USA | Flash Point | 48.2 °F | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of Vitamin B12Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.Target: OthersVitamin B12 is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis (especially odd chain fatty acids) and energy production. Vitamin B12 normally plays a significant role in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production. However, many (though not all) of the effects of functions of B12 can be replaced by sufficient quantities of folic acid (vitamin B9), since B12 is used to regenerate folate in the body. Most vitamin B12 deficiency symptoms are actually folate deficiency symptoms, since they include all the effects of pernicious anemia and megaloblastosis, which are due to poor synthesis of DNA when the body does not have a proper supply of folic acid for the production of thymine due to methyl trapping. When sufficient folic acid is available, all known B12 related deficiency syndromes normalize, save those narrowly connected with the vitamin B12-dependent enzymes Methylmalonyl Coenzyme A mutase, and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase; and the buildup of their respective substrates (methylmalonic acid, MMA) and homocysteine.Coenzyme B12's reactive C-Co bond participates in three main types of enzyme-catalyzed reactions [1, 2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | cyanocob(III)alamin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.Target: OthersVitamin B12 is a water-soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood. It is one of the eight B vitamins. It is normally involved in the metabolism of every cell of the human body, especially affecting DNA synthesis and regulation, but also fatty acid synthesis (especially odd chain fatty acids) and energy production. Vitamin B12 normally plays a significant role in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production. However, many (though not all) of the effects of functions of B12 can be replaced by sufficient quantities of folic acid (vitamin B9), since B12 is used to regenerate folate in the body. Most vitamin B12 deficiency symptoms are actually folate deficiency symptoms, since they include all the effects of pernicious anemia and megaloblastosis, which are due to poor synthesis of DNA when the body does not have a proper supply of folic acid for the production of thymine due to methyl trapping. When sufficient folic acid is available, all known B12 related deficiency syndromes normalize, save those narrowly connected with the vitamin B12-dependent enzymes Methylmalonyl Coenzyme A mutase, and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase; and the buildup of their respective substrates (methylmalonic acid, MMA) and homocysteine.Coenzyme B12's reactive C-Co bond participates in three main types of enzyme-catalyzed reactions [1, 2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Melting Point | >300ºC |
|---|---|
| Molecular Formula | C63H88CoN14O14P |
| Molecular Weight | 1355.365 |
| Exact Mass | 1354.567383 |
| PSA | 479.70000 |
| LogP | 6.57018 |
| InChIKey | FDJOLVPMNUYSCM-IQFXPAJWSA-L |
| SMILES | CC1=C2N=C(C=C3N=C(C(C)=C4[N-]C(C(CC(N)=O)C4(C)CCC(=O)NCC(C)OP(=O)([O-])OC4C(CO)OC(n5cnc6cc(C)c(C)cc65)C4O)C4(C)N=C1C(CCC(N)=O)C4(C)CC(N)=O)C(CCC(N)=O)C3(C)C)C(CCC(N)=O)C2(C)CC(N)=O.[C-]#N.[Co+3] |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | S24/25 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| RTECS | GG3750000 |
| HS Code | 2936260000 |
| Flash Point(F) | 48.2 °F |
| Flash Point(C) | 9 °C |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
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| DownStream 2 | |
CAS#:13422-55-4
CAS#:75-18-3This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2936260000 |
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This table lists relevant public references with title, journal and publication metadata for this compound.
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Alanine Scanning Mutagenesis Identifies an Asparagine–Arginine–Lysine Triad Essential to Assembly of the Shell of the Pdu Microcompartment
J. Mol. Biol. 426(12) , 2328-45, (2014) Bacterial microcompartments (MCPs) are the simplest organelles known. They function to enhance metabolic pathways by confining several related enzymes inside an all-protein envelope called the shell. ... |
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Tissue vitamin concentrations are maintained constant by changing the urinary excretion rate of vitamins in rats' restricted food intake.
Biosci. Biotechnol. Biochem. 78(12) , 2102-9, (2014) We previously reported that mild food restriction induces a reduction in tryptophan-nicotinamide conversion, which helps to explain why death secondary to pellagra is pandemic during the hungry season... |
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Effect of concentrate feeder design on performance, eating and animal behavior, welfare, ruminal health, and carcass quality in Holstein bulls fed high-concentrate diets.
J. Anim. Sci. 93 , 3018-33, (2015) A total of 240 Holstein bulls (121 ± 2.0 kg initial BW; 99 ± 1.0 d of age), from 2 consecutive fattening cycles, were randomly allocated in 1 of 6 pens and assigned to 1 of the 3 treatments consisting... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| cob(II)alamin |
| vitral |
| Vb12 |
| cotel |
| vibalt |
| embiol |
| Vitamin b12 |
| Cyanocobalamin |
| CN-13-epiCbl |
| covit |
| cn-b12 |
| vitamin B-12 |
| cyomin |
| EINECS 200-680-0 |
| MFCD00151092 |
| Bedoz |
| CN-CBL |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the CAS number of cyanocob(III)alamin? |
| A: CAS number of cyanocob(III)alamin is 68-19-9. |
| Q: What English synonyms does cyanocob(III)alamin have? |
| A: English synonyms of cyanocob(III)alamin: cob(II)alamin, vitral, Vb12, cotel, vibalt, embiol, Vitamin b12, Cyanocobalamin, CN-13-epiCbl, covit, cn-b12, vitamin B-12, cyomin, EINECS 200-680-0, MFCD00151092, Bedoz, CN-CBL. |
| Q: What is the molecular formula of cyanocob(III)alamin? |
| A: Molecular formula of cyanocob(III)alamin is C63H88CoN14O14P. |
| Q: What is the polar surface area (PSA) of cyanocob(III)alamin? |
| A: Polar surface area (PSA) of cyanocob(III)alamin is 479.70000. |
| Q: What is the SMILES notation of cyanocob(III)alamin? |
| A: SMILES notation of cyanocob(III)alamin is CC1=C2N=C(C=C3N=C(C(C)=C4[N-]C(C(CC(N)=O)C4(C)CCC(=O)NCC(C)OP(=O)([O-])OC4C(CO)OC(n5cnc6cc(C)c(C)cc65)C4O)C4(C)N=C1C(CCC(N)=O)C4(C)CC(N)=O)C(CCC(N)=O)C3(C)C)C(CCC(N)=O)C2(C)CC(N)=O.[C-]#N.[Co+3]. |
| Q: What are the downstream products of cyanocob(III)alamin? |
| A: Related downstream products(CAS) of cyanocob(III)alamin: 13422-55-4;75-18-3. |
| Q: What is the InChIKey of cyanocob(III)alamin? |
| A: InChIKey of cyanocob(III)alamin is FDJOLVPMNUYSCM-IQFXPAJWSA-L. |
| Q: What is the English name of cyanocob(III)alamin? |
| A: The English name of cyanocob(III)alamin is cyanocob(III)alamin. |
| Q: What is the LogP of cyanocob(III)alamin? |
| A: LogP of cyanocob(III)alamin is 6.57018. |
| Q: What is the molecular weight of cyanocob(III)alamin? |
| A: Molecular weight of cyanocob(III)alamin is 1355.365. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |