Hexamethylphosphoramide structure
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Common Name | Hexamethylphosphoramide | ||
|---|---|---|---|---|
| CAS Number | 680-31-9 | Molecular Weight | 179.20000 | |
| Density | 1.03 g/mL at 25 °C(lit.) | Boiling Point | 230-232 °C740 mm Hg(lit.) | |
| Molecular Formula | C6H18N3OP | Melting Point | 7 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 222 °F | |
| Symbol |
GHS08 |
Signal Word | Danger | |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | hexamethylphosphoric triamide |
|---|---|
| Synonym | More Synonyms |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.03 g/mL at 25 °C(lit.) |
|---|---|
| Boiling Point | 230-232 °C740 mm Hg(lit.) |
| Melting Point | 7 °C(lit.) |
| Molecular Formula | C6H18N3OP |
| Molecular Weight | 179.20000 |
| Flash Point | 222 °F |
| Exact Mass | 179.11900 |
| PSA | 36.60000 |
| LogP | 0.77930 |
| Vapour density | 6.18 (vs air) |
| Vapour Pressure | 0.07 mm Hg ( 25 °C) |
| Index of Refraction | n20/D 1.459(lit.) |
| InChIKey | GNOIPBMMFNIUFM-UHFFFAOYSA-N |
| SMILES | CN(C)P(=O)(N(C)C)N(C)C |
| Stability | Stable. Incompatible with strong acids, strong oxidizing agents. |
| Water Solubility | Miscible |
| Freezing Point | 7℃ |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H340-H350 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R45;R46 |
| Safety Phrases | S53-S45 |
| RIDADR | 2810 |
| WGK Germany | 3 |
| RTECS | TD0875000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 10 | |
|---|---|
| DownStream 10 | |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Mechanistic insight into the formation of cationic naked nanocrystals generated under equilibrium control.
J. Am. Chem. Soc. 136(44) , 15702-10, (2014) Cationic naked nanocrystals (NCs) are useful building units for assembling hierarchical mesostructured materials. Until now, their preparation required strongly electrophilic reagents that irreversibl... |
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Modified in vivo comet assay detects the genotoxic potential of 14-hydroxycodeinone, an α,β-unsaturated ketone in oxycodone.
Environ. Mol. Mutagen. 56 , 777-87, (2015) 14-Hydroxycodeinone (14-HC) is an α,β-unsaturated ketone impurity found in oxycodone drug substance and has a structural alert for genotoxicity. 14-HC was tested in a combined Modified and Standard Co... |
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Lewis base-catalyzed conjugate reduction and reductive aldol reaction of alpha,beta-unsaturated ketones using trichlorosilane.
Chem. Commun. (Camb.) (36) , 4309-11, (2008) Lewis bases such as Ph3P=O and HMPA catalyze the 1,4-reduction of alpha,beta-unsaturated ketones with trichlorosilane, and because the 1,2-reduction of aldehydes scarcely proceeded under the condition... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| hexamethyl |
| HMPTA |
| hexamethylphosphoric triamide |
| HPT |
| hexamethylphosphoric acid triamide |
| HEXAMETAPOL |
| Hexamethylphosphoramide |
| ENT 50,882 |
| MFCD00008303 |
| EINECS 211-653-8 |
| HEMPA |
| HMPA |
| tris(dimethylamino)phosphine oxide |
| hexamethyl-phosphoric triamide |
| PO(NMe2)3 (hexamethylphosphorous triamide) |
| N,N,N',N',N'',N''-hexamethyl-phosphoric triamide |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the SMILES notation of hexamethylphosphoric triamide? |
| A: SMILES notation of hexamethylphosphoric triamide is CN(C)P(=O)(N(C)C)N(C)C. |
| Q: What is the InChIKey of hexamethylphosphoric triamide? |
| A: InChIKey of hexamethylphosphoric triamide is GNOIPBMMFNIUFM-UHFFFAOYSA-N. |
| Q: What is the safety information for hexamethylphosphoric triamide? |
| A: Safety information for hexamethylphosphoric triamide: S53-S45. |
| Q: What English synonyms does hexamethylphosphoric triamide have? |
| A: English synonyms of hexamethylphosphoric triamide: hexamethyl, HMPTA, hexamethylphosphoric triamide, HPT, hexamethylphosphoric acid triamide, HEXAMETAPOL, Hexamethylphosphoramide, ENT 50,882, MFCD00008303, EINECS 211-653-8, HEMPA, HMPA, tris(dimethylamino)phosphine oxide, hexamethyl-phosphoric triamide, PO(NMe2)3 (hexamethylphosphorous triamide), N,N,N',N',N'',N''-hexamethyl-phosphoric triamide. |
| Q: What is the LogP of hexamethylphosphoric triamide? |
| A: LogP of hexamethylphosphoric triamide is 0.77930. |
| Q: What is the molecular formula of hexamethylphosphoric triamide? |
| A: Molecular formula of hexamethylphosphoric triamide is C6H18N3OP. |
| Q: What is the boiling point of hexamethylphosphoric triamide? |
| A: Boiling point of hexamethylphosphoric triamide is 230-232 °C740 mm Hg(lit.). |
| Q: What is the English name of hexamethylphosphoric triamide? |
| A: The English name of hexamethylphosphoric triamide is hexamethylphosphoric triamide. |
| Q: How is the water solubility of hexamethylphosphoric triamide? |
| A: Water solubility of hexamethylphosphoric triamide: Miscible. |
| Q: What is the molecular weight of hexamethylphosphoric triamide? |
| A: Molecular weight of hexamethylphosphoric triamide is 179.20000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |
| Zhongshan Xingrui Chemical Co. , Ltd. |