Amino-PEG4-C2-amine

Modify Date: 2024-01-11 15:29:44

Amino-PEG4-C2-amine Structure
Amino-PEG4-C2-amine structure
Common Name Amino-PEG4-C2-amine
CAS Number 68960-97-4 Molecular Weight 236.30900
Density N/A Boiling Point 139 °C/0.2 mmHg
Molecular Formula C10H24N2O4 Melting Point N/A
MSDS N/A Flash Point 157 °C

 Use of Amino-PEG4-C2-amine


Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.

 Names

Name 2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanamine
Synonym More Synonyms

 Amino-PEG4-C2-amine Biological Activity

Description Amino-PEG4-C2-amine is a PEG-based (4 units) PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

 Chemical & Physical Properties

Boiling Point 139 °C/0.2 mmHg
Molecular Formula C10H24N2O4
Molecular Weight 236.30900
Flash Point 157 °C
Exact Mass 236.17400
PSA 88.96000
LogP 0.37080
Index of Refraction 1.47

 Safety Information

Hazard Class 8.0

 Synthetic Route

~89%

Amino-PEG4-C2-amine Structure

Amino-PEG4-C2-amine

CAS#:68960-97-4

Literature: Liu, Kun; Meyerhoff, Mark E. Journal of Materials Chemistry, 2012 , vol. 22, # 36 p. 18784 - 18787

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Amino-PEG4-C2-amine Structure

Amino-PEG4-C2-amine

CAS#:68960-97-4

Literature: Ciuffarin, Ennio; Isola, Mauro; Leoni, Piero Journal of Organic Chemistry, 1981 , vol. 46, # 15 p. 3064 - 3070

 Synonyms

1,14-diamino-3,6,9,12-tetraoxatetradecane
3,6,9,12-Tetraoxatetradecane-1,14-diamine
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