166388-57-4
166388-57-4 structure
- Name: Azido-PEG2-C2-amine
- Chemical Name: 2-[2-(2-azidoethoxy)ethoxy]ethanamine
- CAS Number: 166388-57-4
- Molecular Formula: C6H14N4O2
- Molecular Weight: 174.20100
- Catalog: Chemical reagent Organic reagent Azide
- Create Date: 2019-02-04 12:06:26
- Modify Date: 2025-08-24 21:01:18
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Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
| Name | 2-[2-(2-azidoethoxy)ethoxy]ethanamine |
|---|---|
| Synonyms |
2-(2-(2-azidoethoxy)exthoxy)ethanamine
1-AMINO-8-AZIDO-3,5-DIOXAOCTANE Amino-PEG2-Azide 2-azidoethyloxyethyloxyethylamine 2-(2-(2-azidoethoxy)ethoxy)ethanamine 1-(2-AMINOETHOXY)-2-(2-AZIDOETHOXY)ETHANE 2-[2-(2-azidoethoxy)-ethoxy]-ethylamine |
| Description | Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
[2]. Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1. |
| Molecular Formula | C6H14N4O2 |
|---|---|
| Molecular Weight | 174.20100 |
| Exact Mass | 174.11200 |
| PSA | 94.23000 |
| LogP | 0.44166 |
| Storage condition | 2-8°C |
| Precursor 8 | |
|---|---|
| DownStream 0 | |