Azido-PEG2-C2-amine
Azido-PEG2-C2-amine structure
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Common Name | Azido-PEG2-C2-amine | ||
|---|---|---|---|---|
| CAS Number | 166388-57-4 | Molecular Weight | 174.20100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C6H14N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Azido-PEG2-C2-amineAzido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 2-[2-(2-azidoethoxy)ethoxy]ethanamine |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
[2]. Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1. |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C6H14N4O2 |
|---|---|
| Molecular Weight | 174.20100 |
| Exact Mass | 174.11200 |
| PSA | 94.23000 |
| LogP | 0.44166 |
| InChIKey | ZHWGWSYNZIZTFL-UHFFFAOYSA-N |
| SMILES | [N-]=[N+]=NCCOCCOCCN |
| Storage condition | 2-8°C |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~99%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Klein, Emmanuel; DeBonis, Salvatore; Thiede, Bernd; Skoufias, Dimitrios A.; Kozielski, Frank; Lebeau, Luc Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 19 p. 6474 - 6488 |
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~76%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Li, Ying; Schaffer, Paul; Perrin, David M. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 23 p. 6313 - 6316 |
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~57%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Lu, Yan; Gervay-Hague, Jacquelyn Carbohydrate Research, 2007 , vol. 342, # 12-13 p. 1636 - 1650 |
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Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 6 p. 1499 - 1503 |
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Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Zheng, Hong; Wang, Fang; Wang, Qin; Gao, Jianmin Journal of the American Chemical Society, 2011 , vol. 133, # 39 p. 15280 - 15283 |
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Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Carbohydrate Research, , vol. 342, # 12-13 p. 1636 - 1650 |
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~%
Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Journal of the American Chemical Society, , vol. 133, # 39 p. 15280 - 15283 |
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Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 45 p. 18809 - 18815 |
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Azido-PEG2-C2-amine CAS#:166388-57-4 |
| Literature: Journal of the American Chemical Society, , vol. 134, # 45 p. 18809 - 18815 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 8 | |
|---|---|
| DownStream 0 | |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 2-(2-(2-azidoethoxy)exthoxy)ethanamine |
| 1-AMINO-8-AZIDO-3,5-DIOXAOCTANE |
| Amino-PEG2-Azide |
| 2-azidoethyloxyethyloxyethylamine |
| 2-(2-(2-azidoethoxy)ethoxy)ethanamine |
| 1-(2-AMINOETHOXY)-2-(2-AZIDOETHOXY)ETHANE |
| 2-[2-(2-azidoethoxy)-ethoxy]-ethylamine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: Main uses of 2-[2-(2-azidoethoxy)ethoxy]ethanamine: Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Q: What is the molecular formula of 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: Molecular formula of 2-[2-(2-azidoethoxy)ethoxy]ethanamine is C6H14N4O2. |
| Q: What English synonyms does 2-[2-(2-azidoethoxy)ethoxy]ethanamine have? |
| A: English synonyms of 2-[2-(2-azidoethoxy)ethoxy]ethanamine: 2-(2-(2-azidoethoxy)exthoxy)ethanamine, 1-AMINO-8-AZIDO-3,5-DIOXAOCTANE, Amino-PEG2-Azide, 2-azidoethyloxyethyloxyethylamine, 2-(2-(2-azidoethoxy)ethoxy)ethanamine, 1-(2-AMINOETHOXY)-2-(2-AZIDOETHOXY)ETHANE, 2-[2-(2-azidoethoxy)-ethoxy]-ethylamine. |
| Q: What is the SMILES notation of 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: SMILES notation of 2-[2-(2-azidoethoxy)ethoxy]ethanamine is [N-]=[N+]=NCCOCCOCCN. |
| Q: What is the LogP of 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: LogP of 2-[2-(2-azidoethoxy)ethoxy]ethanamine is 0.44166. |
| Q: What is the molecular weight of 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: Molecular weight of 2-[2-(2-azidoethoxy)ethoxy]ethanamine is 174.20100. |
| Q: What are the upstream materials of 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: Related upstream materials(CAS) of 2-[2-(2-azidoethoxy)ethoxy]ethanamine: 59559-06-7;929-59-9;950683-55-3;112-26-5;112-27-6;153086-78-3;19249-03-7;139115-92-7. |
| Q: What are the storage conditions for 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: Storage conditions for 2-[2-(2-azidoethoxy)ethoxy]ethanamine: 2-8°C. |
| Q: What is the English name of 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: The English name of 2-[2-(2-azidoethoxy)ethoxy]ethanamine is 2-[2-(2-azidoethoxy)ethoxy]ethanamine. |
| Q: What is the InChIKey of 2-[2-(2-azidoethoxy)ethoxy]ethanamine? |
| A: InChIKey of 2-[2-(2-azidoethoxy)ethoxy]ethanamine is ZHWGWSYNZIZTFL-UHFFFAOYSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |