Sp-cAMPS structure
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Common Name | Sp-cAMPS | ||
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CAS Number | 71774-13-5 | Molecular Weight | 345.27200 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C10H12N5O5PS | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Name | O3',O5'-hydroxythiophosphoryl-adenosine |
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Description | Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA I 和 PKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM[1][2][3]. |
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Related Catalog | |
Target |
PKA I PKA II PDE3A:47.6 μM (Ki) PDE10 GAF domain:50 μM (EC50) |
In Vitro | Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca2+ can be mimicked by Sp-cAMPS[4]. |
In Vivo | In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals[5]. |
References |
Molecular Formula | C10H12N5O5PS |
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Molecular Weight | 345.27200 |
Exact Mass | 345.03000 |
PSA | 179.67000 |
LogP | 0.53080 |