D-Biotin

Modify Date: 2024-01-02 13:48:04

D-Biotin structure	Common Name	D-Biotin
	CAS Number	58-85-5	Molecular Weight	244.311
	Density	1.6±0.1 g/cm3	Boiling Point	492.3±55.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₆N₂O₃S	Melting Point	231-233 °C(lit.)
	MSDS	Chinese USA	Flash Point	251.5±31.5 °C

Use of D-Biotin

Biotin is a water-soluble, enzyme co-factor present in minute amounts in every living cell.Target: OthersBiotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. In addition, biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. The dietary biotin intake in Western populations has been estimated to be 35 to 70 microg/d (143-287 nmol/d). Recent studies suggest that humans absorb biotin nearly completely. Conditions that may increase biotin requirements in humans include pregnancy, lactation, and therapy with anticonvulsants or lipoic acid [1, 2].

Name	biotin
Synonym	More Synonyms

Description	Biotin is a water-soluble, enzyme co-factor present in minute amounts in every living cell.Target: OthersBiotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. In addition, biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. The dietary biotin intake in Western populations has been estimated to be 35 to 70 microg/d (143-287 nmol/d). Recent studies suggest that humans absorb biotin nearly completely. Conditions that may increase biotin requirements in humans include pregnancy, lactation, and therapy with anticonvulsants or lipoic acid [1, 2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Natural Products >> Others
References	[1]. Zempleni, J. and D.M. Mock, Biotin biochemistry and human requirements. J Nutr Biochem, 1999. 10(3): p. 128-38. [2]. Mock, D.M., Biotin status: which are valid indicators and how do we know? J Nutr, 1999. 129(2S Suppl): p. 498S-503S.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Natural Products >> Others

References

[1]. Zempleni, J. and D.M. Mock, Biotin biochemistry and human requirements. J Nutr Biochem, 1999. 10(3): p. 128-38.

[2]. Mock, D.M., Biotin status: which are valid indicators and how do we know? J Nutr, 1999. 129(2S Suppl): p. 498S-503S.

Density	1.6±0.1 g/cm3
Boiling Point	492.3±55.0 °C at 760 mmHg
Melting Point	231-233 °C(lit.)
Molecular Formula	C₁₀H₁₆N₂O₃S
Molecular Weight	244.311
Flash Point	251.5±31.5 °C
Exact Mass	244.088165
PSA	103.73000
LogP	0.03
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.717

D-Biotin MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XJ9088200

CHEMICAL NAME :: 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3a-alpha,4-beta, 6a-alpha))-

CAS REGISTRY NUMBER :: 58-85-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H16-N2-O3-S

MOLECULAR WEIGHT :: 244.34

WISWESSER LINE NOTATION :: T55 BMVM GSTJ H4VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 14-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 22,181,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 100 mg/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: CUSCAM Current Science. (Current Science Assoc., Sadashivanagar P.O., Bangalore 560 080, India) V.1- 1932- Volume(issue)/page/year: 42,613,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 1-2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JNSVA5 Journal of Nutritional Science and Vitaminology. (Business Center for Academic Soc. Japan, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.19- 1973- Volume(issue)/page/year: 21,89,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 17 mg/kg

SEX/DURATION :: female 1-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 52,149,1996 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80381 No. of Facilities: 129 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 8306 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80381 No. of Facilities: 1674 (estimated) No. of Industries: 9 No. of Occupations: 41 No. of Employees: 46583 (estimated) No. of Female Employees: 22672 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	20/21/22-36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	XJ9088200
HS Code	29362930

Precursor 5
CAS#:292151-19-0 (3aS,4S,6aR)-5-... CAS#:31099-31-7 (3aS,4S,6aR)-1,... CAS#:83541-80-4 [3aS-(3aα,4β,6a... CAS#:24459-54-9 N,N'-dibenzylbi...
CAS#:28092-52-6 (3aS-cis)-1,3-d...
DownStream 9
CAS#:33755-53-2 (+)-Biotin-ONP CAS#:576-19-2 Biocytin CAS#:35013-72-0 Biotin NHS CAS#:359860-27-8 Amine-PEG3-Biotin
CAS#:71-36-3 Butanol CAS#:504-63-2 1,3-Propanediol CAS#:58-85-5 D-Biotin CAS#:2387-23-7 1,3-Dicyclohexylurea
CAS#:89889-52-1 Biotin-LC-LC-NHS

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.

J. Nutr. 144(12) , 1977-84, (2014)

Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequa...

Characterization and tissue distribution of conjugated metabolites of pyrene in the rat.

J. Vet. Med. Sci. 77 , 1261-7, (2015)

Pyrene (PY) is a polycyclic aromatic hydrocarbon (PAH) that is often used as a biomarker for human and wildlife exposure to PAHs. As the metabolites of PAHs, similar to their parent compounds, pose pu...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

D(+)-Biotin

1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-

cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid

(+)-Biotin

EINECS 200-399-3

Bios-IIb

biotina

(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid

Rovimix H2

biotine

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Vitamin H

BIOS H

1H-Thieno[3,4-d]imidazole-6-pentanoic acid, 3a,4,6,6a-tetrahydro-2-hydroxy-, (3aR,6S,6aS)-

5-[(3aR,6S,6aS)-2-Hydroxy-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]pentanoic acid

5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid

biotin

Meribin

Ritatin

BIOTINUM

Lutavit H2

MFCD00005541

Factor S

biosii

Biodermatin

D-(+)-Biotin

D-Biotin

Vitamin B7

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China
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D-Biotin

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