D-Biotin
D-Biotin structure
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Common Name | D-Biotin | ||
|---|---|---|---|---|
| CAS Number | 58-85-5 | Molecular Weight | 244.311 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 492.3±55.0 °C at 760 mmHg | |
| Molecular Formula | C10H16N2O3S | Melting Point | 231-233 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 251.5±31.5 °C | |
Use of D-BiotinBiotin is a water-soluble, enzyme co-factor present in minute amounts in every living cell.Target: OthersBiotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. In addition, biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. The dietary biotin intake in Western populations has been estimated to be 35 to 70 microg/d (143-287 nmol/d). Recent studies suggest that humans absorb biotin nearly completely. Conditions that may increase biotin requirements in humans include pregnancy, lactation, and therapy with anticonvulsants or lipoic acid [1, 2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | biotin |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Biotin is a water-soluble, enzyme co-factor present in minute amounts in every living cell.Target: OthersBiotin is necessary for cell growth, the production of fatty acids, and the metabolism of fats and amino acids. It plays a role in the citric acid cycle, which is the process by which biochemical energy is generated during aerobic respiration. Biotin is a coenzyme for carboxylase enzymes, involved in the synthesis of fatty acids, isoleucine, and valine, and in gluconeogenesis. In addition, biotin is widely used throughout the biotechnology industry to conjugate proteins for biochemical assays. The dietary biotin intake in Western populations has been estimated to be 35 to 70 microg/d (143-287 nmol/d). Recent studies suggest that humans absorb biotin nearly completely. Conditions that may increase biotin requirements in humans include pregnancy, lactation, and therapy with anticonvulsants or lipoic acid [1, 2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 492.3±55.0 °C at 760 mmHg |
| Melting Point | 231-233 °C(lit.) |
| Molecular Formula | C10H16N2O3S |
| Molecular Weight | 244.311 |
| Flash Point | 251.5±31.5 °C |
| Exact Mass | 244.088165 |
| PSA | 103.73000 |
| LogP | 0.03 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.717 |
| InChIKey | YBJHBAHKTGYVGT-ZKWXMUAHSA-N |
| SMILES | O=C(O)CCCCC1SCC2NC(=O)NC21 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22-36/37/38 |
| Safety Phrases | S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | XJ9088200 |
| HS Code | 29362930 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 5 | |
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| DownStream 9 | |
![(3aS,4S,6aR)-5-(1,3-dibenzyl-2,3,3a,4,6,6a-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-5-ylidene)pentanoic acid ethyl ester Structure](https://image.chemsrc.com/caspic/294/292151-19-0.png)
CAS#:292151-19-0![(3aS,4S,6aR)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2(3H)-one-4-ylpentane nitrile Structure](https://image.chemsrc.com/caspic/223/31099-31-7.png)
CAS#:31099-31-7![[3aS-(3aα,4β,6aα)]-Hexahydro-2-oxo-3-(phenylmethyl)-1H-thieno[3,4-d]imidazole-4-pentanoic acid methyl ester Structure](https://image.chemsrc.com/caspic/325/83541-80-4.png)
CAS#:83541-80-4
CAS#:24459-54-9![(3aS-cis)-1,3-dibenzyltetrahydro-1H-thieno[3,4-d]imidazole-2,4-dione Structure](https://image.chemsrc.com/caspic/360/28092-52-6.png)
CAS#:28092-52-6
CAS#:33755-53-2
CAS#:576-19-2
CAS#:35013-72-0
CAS#:359860-27-8
CAS#:71-36-3
CAS#:504-63-2
CAS#:2387-23-7
CAS#:89889-52-1This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2934999090 |
|---|---|
| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
J. Nutr. 144(12) , 1977-84, (2014) Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequa... |
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Characterization and tissue distribution of conjugated metabolites of pyrene in the rat.
J. Vet. Med. Sci. 77 , 1261-7, (2015) Pyrene (PY) is a polycyclic aromatic hydrocarbon (PAH) that is often used as a biomarker for human and wildlife exposure to PAHs. As the metabolites of PAHs, similar to their parent compounds, pose pu... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| D(+)-Biotin |
| cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid |
| (+)-Biotin |
| EINECS 200-399-3 |
| Bios-IIb |
| biotina |
| (3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid |
| Rovimix H2 |
| biotine |
| Rovimix H 2 |
| Vitamin H |
| BIOS H |
| 5-[(3aR,6S,6aS)-2-Hydroxy-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl]pentanoic acid |
| 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid |
| biotin |
| Meribin |
| Ritatin |
| BIOTINUM |
| Lutavit H2 |
| MFCD00005541 |
| Factor S |
| biosii |
| Biodermatin |
| D-(+)-Biotin |
| D-Biotin |
| Vitamin B7 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the melting point of biotin? |
| A: Melting point of biotin is 231-233 °C(lit.). |
| Q: What is the LogP of biotin? |
| A: LogP of biotin is 0.03. |
| Q: What is the molecular formula of biotin? |
| A: Molecular formula of biotin is C10H16N2O3S. |
| Q: What is the InChIKey of biotin? |
| A: InChIKey of biotin is YBJHBAHKTGYVGT-ZKWXMUAHSA-N. |
| Q: What are the upstream materials of biotin? |
| A: Related upstream materials(CAS) of biotin: 292151-19-0;31099-31-7;83541-80-4;24459-54-9;28092-52-6. |
| Q: What is the safety information for biotin? |
| A: Safety information for biotin: S24/25. |
| Q: What is the SMILES notation of biotin? |
| A: SMILES notation of biotin is O=C(O)CCCCC1SCC2NC(=O)NC21. |
| Q: What is the polar surface area (PSA) of biotin? |
| A: Polar surface area (PSA) of biotin is 103.73000. |
| Q: What is the English name of biotin? |
| A: The English name of biotin is biotin. |
| Q: What are the downstream products of biotin? |
| A: Related downstream products(CAS) of biotin: 33755-53-2;576-19-2;35013-72-0;359860-27-8;71-36-3;504-63-2;58-85-5;2387-23-7;89889-52-1. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |