Statil

Modify Date: 2026-07-02 21:23:27

Statil structure	Common Name	Statil
	CAS Number	72702-95-5	Molecular Weight	391.191
	Density	1.6±0.1 g/cm3	Boiling Point	576.3±60.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₂BrFN₂O₃	Melting Point	184-186ºC (DEC.)
	MSDS	N/A	Flash Point	302.4±32.9 °C

Use of Statil

Statil (Ponalrestat) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Statil selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Statil inhibits the conversion of glucose to sorbitol[1][2][3].

Name	2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxophthalazin-1-yl]acetic acid
Synonym	More Synonyms

Description	Statil (Ponalrestat) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Statil selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Statil inhibits the conversion of glucose to sorbitol[1][2][3].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Aldose Reductase Research Areas >> Metabolic Disease
Target	Ki: 7.7 nM (ALR2) and 60 μM (ALR1)[1]
In Vitro	Statil (Ponalrestat; 1, 10, 100 μM; 6 hours) reduces PGF2αproduction in response to IL-1 in both cultured endometrial cells and endometrial explants[2].
In Vivo	Statil (Ponalrestat; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition[3]. Animal Model: Adult female Sprague-Dawley rats[3] Dosage: 10, 50 mg/kg Administration: Orally; daily; 8 weeks Result: Reduced sorbitol accumulation.
References	[1]. Ward WH, et al. Ponalrestat: a potent and specific inhibitor of aldose reductase. Biochem Pharmacol. 1990 Jan 15;39(2):337-46. [2]. Bresson E, et al. The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium. J Clin Endocrinol Metab. 2011 Jan;96(1):210-9. [3]. Calcutt NA, et al. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia. 2004 Apr;47(4):718-24.

Density	1.6±0.1 g/cm3
Boiling Point	576.3±60.0 °C at 760 mmHg
Melting Point	184-186ºC (DEC.)
Molecular Formula	C₁₇H₁₂BrFN₂O₃
Molecular Weight	391.191
Flash Point	302.4±32.9 °C
Exact Mass	390.001526
PSA	72.19000
LogP	2.70
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.663
InChIKey	LKBFFDOJUKLQNY-UHFFFAOYSA-N
SMILES	O=C(O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c2ccccc12
Storage condition	-20°C

Risk Phrases	36/37/38
Safety Phrases	26-36/37/39
HS Code	2933990090

4-Bromo-1-(brom...

CAS#:76283-09-5

1-Phthalazineac...

CAS#:25947-13-1

~52%

Statil

CAS#:72702-95-5

Learn More

Literature: Sriram, Dharmarajan; Yogeeswari, Perumal; Senthilkumar, Palaniappan; Sangaraju, Dewakar; Nelli, Rohit; Banerjee, Debjani; Bhat, Pritesh; Manjashetty, Thimmappa H. Chemical Biology and Drug Design, 2010 , vol. 75, # 4 p. 381 - 391

Precursor 2
CAS#:76283-09-5 4-Bromo-1-(brom... CAS#:25947-13-1 1-Phthalazineac...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist

Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315

Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library

Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity

Name: EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Rea...
Source: Broad Institute
Target: histone-lysine N-methyltransferase EZH2 isoform a [Homo sapiens]
External Id: 2125-01_Inhibitor_SinglePoint_HTS_Activity

Name: In vitro inhibitory activity against L-Hexonate Dehydrogenase (L-HDH) from rat kidney...
Source: ChEMBL
Target: Aldo-keto reductase family 1 member B1
External Id: CHEMBL878705

Name: Effective dose of aldose reductase was evaluated by measuring galactitol accumulation...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL781302

Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr...
Source: 824
Target: N/A
External Id: SPEC167MG

Name: qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free...
Source: 824
Target: N/A
External Id: SPEC167MR

Name: Validation qHTS for agonist of cAMP-regulated guanine nucleotide exchange factor 3 (E...
Source: NCGC
External Id: epac1-activator-v

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Ponalrestatum

PONALRESTAT

[3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]acetic acid

2-(2-Fluoro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic Acid

3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic Acid

3-(4-bromo-2-fluorobenzyl)-4-oxo-3h-phthalazin-1-ylacetic acid

statil

[3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl]acetic acid

Prodiax

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Statil
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.