Statil
Modify Date: 2024-01-10 18:57:44
Statil structure
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Common Name | Statil | ||
|---|---|---|---|---|
| CAS Number | 72702-95-5 | Molecular Weight | 391.191 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 576.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H12BrFN2O3 | Melting Point | 184-186ºC (DEC.) | |
| MSDS | N/A | Flash Point | 302.4±32.9 °C | |
Use of StatilStatil (Ponalrestat) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Statil selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Statil inhibits the conversion of glucose to sorbitol[1][2][3]. |
| Name | 2-[3-[(4-bromo-2-fluorophenyl)methyl]-4-oxophthalazin-1-yl]acetic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Statil (Ponalrestat) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Statil selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Statil inhibits the conversion of glucose to sorbitol[1][2][3]. |
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| Related Catalog | |
| Target |
Ki: 7.7 nM (ALR2) and 60 μM (ALR1)[1] |
| In Vitro | Statil (Ponalrestat; 1, 10, 100 μM; 6 hours) reduces PGF2αproduction in response to IL-1 in both cultured endometrial cells and endometrial explants[2]. |
| In Vivo | Statil (Ponalrestat; 10, 50 mg/kg; orally; daily; 8 weeks) reduces sorbitol accumulation indicating efficacy of aldose reductase inhibition[3]. Animal Model: Adult female Sprague-Dawley rats[3] Dosage: 10, 50 mg/kg Administration: Orally; daily; 8 weeks Result: Reduced sorbitol accumulation. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 576.3±60.0 °C at 760 mmHg |
| Melting Point | 184-186ºC (DEC.) |
| Molecular Formula | C17H12BrFN2O3 |
| Molecular Weight | 391.191 |
| Flash Point | 302.4±32.9 °C |
| Exact Mass | 390.001526 |
| PSA | 72.19000 |
| LogP | 2.70 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.663 |
| Storage condition | -20°C |
| Risk Phrases | 36/37/38 |
|---|---|
| Safety Phrases | 26-36/37/39 |
| HS Code | 2933990090 |
| Precursor 2 | |
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| DownStream 0 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Ponalrestatum |
| PONALRESTAT |
| [3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydro-1-phthalazinyl]acetic acid |
| 2-(2-Fluoro-4-bromobenzyl)-1,2-dihydro-1-oxophthalazin-4-ylacetic Acid |
| 1-Phthalazineacetic acid, 3-[(4-bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo- |
| 3-[(4-Bromo-2-fluorophenyl)methyl]-3,4-dihydro-4-oxo-1-phthalazineacetic Acid |
| 3-(4-bromo-2-fluorobenzyl)-4-oxo-3h-phthalazin-1-ylacetic acid |
| statil |
| [3-(4-Bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl]acetic acid |
| Prodiax |