SIB-1893
Modify Date: 2024-01-09 07:39:48
SIB-1893 structure
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Common Name | SIB-1893 | ||
|---|---|---|---|---|
| CAS Number | 7370-21-0 | Molecular Weight | 195.26000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H13N | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SIB-1893SIB-1893 is a highly selective non-competitive antagonist for the metabotropic glutamate mGlu5 receptor subtype; displays an IC50 value of 0.3 μM at hmGlu5, compared with > 100 μM at hmGlu1b, hmGlu2, hmGlu6, hmGlu7 and hmGlu8. It positive allosteric modulator at mGlu4 receptors. |
| Name | 2-Methyl-6-[(E)-2-phenylvinyl]pyridine |
|---|---|
| Synonym | More Synonyms |
| Molecular Formula | C14H13N |
|---|---|
| Molecular Weight | 195.26000 |
| Exact Mass | 195.10500 |
| PSA | 12.89000 |
| LogP | 3.56040 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| RIDADR | NONH for all modes of transport |
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Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP.
Br. J. Pharmacol. 138(6) , 1026-30, (2003) We have identified 2-methyl-6-(2-phenylethenyl)pyridine (SIB-1893) and 2-methyl-6-phenylethynyl pyridine hydrochloride (MPEP) as positive allosteric modulators for the hmGluR4. SIB-1893 and MPEP enhan... |
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SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.
J. Pharmacol. Exp. Ther. 290 , 170-181, (1999) Cell lines expressing the human metabotropic glutamate receptor subtype 5a (hmGluR5a) and hmGluR1b were used as targets in an automated high-throughput screening (HTS) system that measures changes in ... |
| 6-METHYL-2-(NAPHTHALEN-2-YL)BENZOIC ACID |
| 2-Methyl-6-(2-naphthyl)-benzoesaeure |
| (E)-2-methyl-6-styrylpyridine |
| 2-Methyl-6-(2-phenylethenyl)pyridine |
| (E)-2-methyl-6-styrypyridine |
| (E)-6-methyl-2-styryl-pyridine |
| 2-methyl-6-[(E)-2-phenylethenyl]pyridine |