O-Desmethyl Midostaurin
Modify Date: 2025-09-18 15:06:38
O-Desmethyl Midostaurin structure
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Common Name | O-Desmethyl Midostaurin | ||
|---|---|---|---|---|
| CAS Number | 740816-86-8 | Molecular Weight | 556.61 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C34H28N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of O-Desmethyl MidostaurinO-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM. |
| Name | O-Desmethyl Midostaurin |
|---|
| Description | O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM. |
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| Related Catalog | |
| Target |
IC50: active metabolite of Midostaurin[1] |
| References |
| Molecular Formula | C34H28N4O4 |
|---|---|
| Molecular Weight | 556.61 |
| InChIKey | PXOCRDZEEXVZQC-AFUPZKSLSA-N |
| SMILES | CN(C(=O)c1ccccc1)C1CC2OC(C)(C1O)n1c3ccccc3c3c4c(c5c6ccccc6n2c5c31)C(=O)NC4 |
| Storage condition | -20°C |