3-Bromo-7-nitro-1H-indazole
3-Bromo-7-nitro-1H-indazole structure
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Common Name | 3-Bromo-7-nitro-1H-indazole | ||
|---|---|---|---|---|
| CAS Number | 74209-34-0 | Molecular Weight | 242.030 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 437.3±25.0 °C at 760 mmHg | |
| Molecular Formula | C7H4BrN3O2 | Melting Point | 175-185 °C | |
| MSDS | USA | Flash Point | 218.3±23.2 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
Use of 3-Bromo-7-nitro-1H-indazole3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1]. |
| Name | 3-Bromo-7-nitro-1H-indazole |
|---|---|
| Synonym | More Synonyms |
| Description | 3-Bromo-7-nitroindazole is a more potent and selective inhibitor of neuronal nitric oxide synthase (nNOS) than eNOS or inducible nitric oxide synthase (iNOS). 3-Bromo-7-nitroindazole affects the intercellular messenger nitric oxide (NO) synthesis throughout the body and brain[1]. |
|---|---|
| Related Catalog | |
| Target |
nNOS[1] |
| References |
| Density | 2.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 437.3±25.0 °C at 760 mmHg |
| Melting Point | 175-185 °C |
| Molecular Formula | C7H4BrN3O2 |
| Molecular Weight | 242.030 |
| Flash Point | 218.3±23.2 °C |
| Exact Mass | 240.948685 |
| PSA | 74.50000 |
| LogP | 2.52 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.764 |
| InChIKey | NFSTZPMYAZRZPC-UHFFFAOYSA-N |
| SMILES | O=[N+]([O-])c1cccc2c(Br)[nH]nc12 |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: 25 mg/mL |
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | 60 |
| Safety Phrases | S53-S22-S36/37/39-S45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
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3-Bromo-7-nitro... CAS#:74209-34-0 |
| Literature: Bouissane, Latifa; El Kazzouli, Said; Leger, Jean-Michel; Jarry, Christian; Rakib, El Mostapha; Khouili, Mostafa; Guillaumet, Gerald Tetrahedron, 2005 , vol. 61, # 34 p. 8218 - 8225 |
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3-Bromo-7-nitro... CAS#:74209-34-0
Learn More
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| Literature: Rakib; Benchidmi; Essassi; El Bouadili; Ibn Mansour; Bellan; Lopez; Lamande Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2000 , vol. 39, # 5 p. 339 - 345 |
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~%
3-Bromo-7-nitro... CAS#:74209-34-0 |
| Literature: Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 5 p. 339 - 345 |
|
~%
3-Bromo-7-nitro... CAS#:74209-34-0 |
| Literature: Justus Liebigs Annalen der Chemie, , vol. 451, p. 285,302 |
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~%
3-Bromo-7-nitro... CAS#:74209-34-0 |
| Literature: Justus Liebigs Annalen der Chemie, , vol. 451, p. 285,302 |
|
~%
3-Bromo-7-nitro... CAS#:74209-34-0 |
| Literature: Justus Liebigs Annalen der Chemie, , vol. 451, p. 285,302 |
CAS#:316810-90-9
CAS#:74209-39-5
CAS#:74209-37-3| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Neuropharmacology 86 , 273-81, (2014) Ketamine is a non-competitive N-methyl-d-aspartate receptor (NMDAR) antagonist of interest in neuropsychiatry. In the present studies, we examined the effects of subanesthetic, low micromolar ketamine... |
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Role of nitric oxide in traumatic brain injury in the rat.
J. Neurosurg. 89 , 807-818, (1998) Although nitric oxide (NO) has been shown to play an important role in the pathophysiological process of cerebral ischemia, its contribution to the pathogenesis of traumatic brain injury (TBI) remains... |
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7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase.
Life Sci. 57 , PL131-PL135, (1995) The effect of 7-nitro indazole (7-NI) and a range of substituted indazole derivatives on nitric oxide synthase (NOS) enzyme activity in homogenates of rat cerebellum, bovine endothelial cells and lung... |
| 3-bromo-7-nitro-2H-indazole |
| 3-Bromo-7-nitro-1H-indazole |
| MFCD00159910 |