Bepridil hydrochloride structure
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Common Name | Bepridil hydrochloride | ||
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CAS Number | 74764-40-2 | Molecular Weight | 421.01600 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C24H37ClN2O2 | Melting Point | 91 ±2° | |
MSDS | USA | Flash Point | N/A |
Use of Bepridil hydrochlorideBepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5]. |
Name | bepridil hydrochloride monohydrate |
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Synonym | More Synonyms |
Description | Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5]. |
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Related Catalog | |
Target |
Ca2+ |
In Vitro | Bepridil hydrochloride hydrate blockades of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary artery[2]. Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC50s of 0.5 μM and 30 μM, respectively in cultured ventricular cells[4]. Bepridil hydrochloride hydrate decreases IKs under blockade of IKr with E4031 (5 μM), in a concentration-dependent manner[5]. |
In Vivo | Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration[6]. |
References |
[1]. A Gill, et al. Pharmacology of Bepridil. Am J Cardiol. 1992 Apr 9;69(11):11D-16D. |
Melting Point | 91 ±2° |
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Molecular Formula | C24H37ClN2O2 |
Molecular Weight | 421.01600 |
Exact Mass | 420.25400 |
PSA | 24.94000 |
LogP | 5.50580 |
Appearance of Characters | powder | white |
Storage condition | Desiccate at RT |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi |
RIDADR | NONH for all modes of transport |
WGK Germany | 2 |
RTECS | UY1162000 |
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