Bepridil hydrochloride

Modify Date: 2026-07-17 15:54:49

Bepridil hydrochloride structure	Common Name	Bepridil hydrochloride
	CAS Number	74764-40-2	Molecular Weight	421.01600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₇ClN₂O₂	Melting Point	91 ±2°
	MSDS	USA	Flash Point	N/A

Use of Bepridil hydrochloride

Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	bepridil hydrochloride monohydrate
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease
Target	Ca2+
In Vitro	Bepridil hydrochloride hydrate blockades of Ca2+-dependent action potentials in vascular smooth muscle of dog coronary artery[2]. Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC50s of 0.5 μM and 30 μM, respectively in cultured ventricular cells[4]. Bepridil hydrochloride hydrate decreases IKs under blockade of IKr with E4031 (5 μM), in a concentration-dependent manner[5].
In Vivo	Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration[6].
References	[1]. A Gill, et al. Pharmacology of Bepridil. Am J Cardiol. 1992 Apr 9;69(11):11D-16D. [2]. D R Harder, et al. Bepridil Blockade of Ca2+-dependent Action Potentials in Vascular Smooth Muscle of Dog Coronary Artery. J Cardiovasc Pharmacol. Jul-Aug 1981;3(4):906-14. [3]. Yasuhide Watanabe. Cardiac Na +/Ca 2+ Exchange Stimulators Among Cardioprotective Drugs. J Physiol Sci. 2019 Nov;69(6):837-849. [4]. A Yatani, et al. Bepridil Block of Cardiac Calcium and Sodium Channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17. [5]. J C Wang, et al. Bepridil Differentially Inhibits Two Delayed Rectifier K(+) Currents, I(Kr) and I(Ks), in Guinea-Pig Ventricular Myocytes. Br J Pharmacol. 1999 Dec;128(8):1733-8. [6]. L Z Benet, et al. Pharmacokinetics and Metabolism of Bepridil. Am J Cardiol. 1985 Mar 15;55(7):8C-13C.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Melting Point	91 ±2°
Molecular Formula	C₂₄H₃₇ClN₂O₂
Molecular Weight	421.01600
Exact Mass	420.25400
PSA	24.94000
LogP	5.50580
Appearance of Characters	powder \| white
InChIKey	UEECHQPWQHYEDE-UHFFFAOYSA-N
SMILES	CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1.Cl.O
Storage condition	Desiccate at RT

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Bepridil hydrochloride MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY1162000

CHEMICAL NAME :: 1-Pyrrolidineethanamine, beta-((2-methylpropoxy)methyl)-N-phenyl-N-(phenylmeth yl)-, monohydrochloride, monohydrate

CAS REGISTRY NUMBER :: 74764-40-2

LAST UPDATED :: 199506

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C24-H34-N2-O.Cl-H.H2-O

MOLECULAR WEIGHT :: 421.08

WISWESSER LINE NOTATION :: T5NTJ AY1O1Y1&1&1NR&1R &GH &QH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6850 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,682,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,682,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >21300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,682,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1955 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2802864

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 23,682,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2802864

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	UY1162000

This table lists relevant public references with title, journal and publication metadata for this compound.

Pulsed infrared radiation excites cultured neonatal spiral and vestibular ganglion neurons by modulating mitochondrial calcium cycling.

J. Neurophysiol. 112(6) , 1246-55, (2014)

Cochlear implants are currently the most effective solution for profound sensorineural hearing loss, and vestibular prostheses are under development to treat bilateral vestibulopathies. Electrical cur...

A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.

Nat. Commun. 5 , 5683, (2014)

Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contus...

Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity.

Drug Metab. Pharmacokinet. 30 , 257-62, (2015)

The aims of this study were to clarify whether the ratio of S- to R-flecainide (S/R ratio) in the serum flecainide concentration was associated with the stereoselectivity of flecainide metabolism, and...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay
Source: 24386
Target: N/A
External Id: Sarm1 Tir NADase inhibitors screen

Name: Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B1
External Id: CHEMBL3039488

Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185

Name: Drug Induced Liver Injury Prediction System (DILIps) validation dataset; compound DIL...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1909323

Name: Literature-mined public compounds from Greene et al multi-species hepatotoxicity mode...
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1697722

Name: Human drug-induced liver injury (DILI) modelling dataset from Ekins et al
Source: ChEMBL
Target: Hepatotoxicity
External Id: CHEMBL1697730

Name: Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimo...
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1B3
External Id: CHEMBL3039491

Total 7, Current Page 1 of 1

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzylpropylaminehydrochloridehydrate

MFCD00065498

Unii-4W2p15D93m

l)-,monohydrochloride,monohydrate

angopril

Bepridil hydrochloride,N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)anilinehydrochloride

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of bepridil hydrochloride monohydrate?

A: SMILES notation of bepridil hydrochloride monohydrate is CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1.Cl.O.

Q: What are the storage conditions for bepridil hydrochloride monohydrate?

A: Storage conditions for bepridil hydrochloride monohydrate: Desiccate at RT.

Q: What is the polar surface area (PSA) of bepridil hydrochloride monohydrate?

A: Polar surface area (PSA) of bepridil hydrochloride monohydrate is 24.94000.

Q: What is the melting point of bepridil hydrochloride monohydrate?

A: Melting point of bepridil hydrochloride monohydrate is 91 ±2°.

Q: What are the uses of bepridil hydrochloride monohydrate?

A: Main uses of bepridil hydrochloride monohydrate: Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5].

Q: What is the InChIKey of bepridil hydrochloride monohydrate?

A: InChIKey of bepridil hydrochloride monohydrate is UEECHQPWQHYEDE-UHFFFAOYSA-N.

Q: What English synonyms does bepridil hydrochloride monohydrate have?

A: English synonyms of bepridil hydrochloride monohydrate: 3-isobutoxy-2-pyrrolidino-n-phenyl-n-benzylpropylaminehydrochloridehydrate, MFCD00065498, Unii-4W2p15D93m, l)-,monohydrochloride,monohydrate, angopril, Bepridil hydrochloride,N-Benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)anilinehydrochloride.

Q: What is the CAS number of bepridil hydrochloride monohydrate?

A: CAS number of bepridil hydrochloride monohydrate is 74764-40-2.

Q: What is the English name of bepridil hydrochloride monohydrate?

A: The English name of bepridil hydrochloride monohydrate is bepridil hydrochloride monohydrate.

Q: What is the molecular weight of bepridil hydrochloride monohydrate?

A: Molecular weight of bepridil hydrochloride monohydrate is 421.01600.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Bepridil hydrochloride
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-PYRROLIDINEETHANAMINE, .BETA.-[(2-METHYLPROPOXY)METHYL]-N-PHENYL-N-(PHENYLMETHYL)-, HYDROCHLORIDE, HYDRATE (1:1:1)
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Price: ￥660/10 mM * 1 mL in DMSO

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