NSC 405020
Modify Date: 2024-01-03 21:45:03
NSC 405020 structure
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Common Name | NSC 405020 | ||
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| CAS Number | 7497-07-6 | Molecular Weight | 260.160 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 353.7±32.0 °C at 760 mmHg | |
| Molecular Formula | C12H15Cl2NO | Melting Point | N/A | |
| MSDS | USA | Flash Point | 167.7±25.1 °C | |
Use of NSC 405020NSC-405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2. IC50 value: > 100 uM [1]Target: MT1-MMP PEX inhibitorNSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP. NSC-405020 dose not affect the ability of MT1-MMP to activate MMP-2 but its ability to degrade COL-I. |
| Name | 3,4-dichloro-N-pentan-2-ylbenzamide |
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| Synonym | More Synonyms |
| Description | NSC-405020 is a novel small molecule inhibitor of MT1-MMP that specifically targets PEX domain rather than the catalytic domain of MT1-MMP with IC50 >100 μM and does not inhibit the catalytic activity of MT1-MMP or MMP-2. IC50 value: > 100 uM [1]Target: MT1-MMP PEX inhibitorNSC-405020 directly interacts with and binds to PEX in a vicinity of Met-328, Arg-330, Asp-376, Met-22 and Ser-470 of the druggable pocket in the full-length MT1-MMP structure, which affects the conformation and flexibility of blades I to IV of the β-propeller resulting in the decrease of the PEX-dependent homodimerization of cellular MT1-MMP. NSC-405020 dose not affect the ability of MT1-MMP to activate MMP-2 but its ability to degrade COL-I. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 353.7±32.0 °C at 760 mmHg |
| Molecular Formula | C12H15Cl2NO |
| Molecular Weight | 260.160 |
| Flash Point | 167.7±25.1 °C |
| Exact Mass | 259.053070 |
| PSA | 29.10000 |
| LogP | 4.29 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.532 |
| Storage condition | room temp |
| 3,4-Dichloro-N-(2-pentanyl)benzamide |
| Benzamide, 3,4-dichloro-N-(1-methylbutyl)- |
| NSC 405020 |