Usnic acid

Modify Date: 2024-01-02 19:35:59

Usnic acid structure	Common Name	Usnic acid
	CAS Number	7562-61-0	Molecular Weight	344.315
	Density	1.5±0.1 g/cm3	Boiling Point	638.2±55.0 °C at 760 mmHg
	Molecular Formula	C₁₈H₁₆O₇	Melting Point	201-203 °C(lit.)
	MSDS	USA	Flash Point	236.0±25.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Usnic acid

(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity[1].

Name	(+)-usnic acid
Synonym	More Synonyms

Description	(+)-Usnic acid is isolated from isolated from lichens, binds at the ATP-binding pocket of mTOR, and inhibits mTORC1/2 activity. (+)-Usnic acid inhibits the phosphorylation of mTOR downstream effectors: Akt (Ser473), 4EBP1, S6K, induces autophay, with anti-cancer activity[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer
Target	mTORC1 mTORC2
References	[1]. Ebrahim HY, et al. Usnic Acid Benzylidene Analogues as Potent Mechanistic Target of Rapamycin Inhibitors for the Control of Breast Malignancies. J Nat Prod. 2017 Apr 28;80(4):932-952.

Density	1.5±0.1 g/cm3
Boiling Point	638.2±55.0 °C at 760 mmHg
Melting Point	201-203 °C(lit.)
Molecular Formula	C₁₈H₁₆O₇
Molecular Weight	344.315
Flash Point	236.0±25.0 °C
Exact Mass	344.089600
PSA	121.13000
LogP	2.30
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.679
Storage condition	2~8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: HP5295050

CHEMICAL NAME :: 3(9bH)-dibenzofuranone, 2,6-diacetyl-1,7,9-trihydroxy-8,9b-dimethyl-, D-

CAS REGISTRY NUMBER :: 7562-61-0

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H16-O7

MOLECULAR WEIGHT :: 344.34

WISWESSER LINE NOTATION :: T B656 EV HO BHJ B1 CQ DV1 JV1 KQ L1 MQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 838 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 31,247,1972 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1500 ug/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 176,249,1955

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	HP5295050
HS Code	2917399090

HS Code	2917399090
Summary	2917399090 aromatic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Proton-shuttling lichen compound usnic acid affects mitochondrial and lysosomal function in cancer cells.

PLoS ONE 7 , e51296, (2012)

The lichen compound usnic acid (UA) is a lipophilic weak acid that acts as a proton shuttle and causes loss of mitochondrial inner membrane potential. In the current study we show that UA treatment in...

Usnic acid

EINECS 231-456-0

(+)-Usniacin

(9bR)-2,6-Diacetyl-1,7,9-trihydroxy-8,9b-dimethyldibenzo[b,d]furan-3(9bH)-one

3(9bH)-Dibenzofuranone, 2,6-diacetyl-1,7,9-trihydroxy-8,9b-dimethyl-, (9bR)-

MFCD00016878

D-Usnic acid

BioBioPha
China
Product Name: Usnic acid
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Usnic acid
Price: ￥168.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (+)-Usniacin
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (+)-Usniacin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

Usnic acid suppliers

Usnic acid price

Usnic acid

Use of Usnic acid

Names

Usnic acid Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Customs

Articles1

Synonyms