APA modulator T4
Modify Date: 2024-01-19 17:37:32
APA modulator T4 structure
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Common Name | APA modulator T4 | ||
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| CAS Number | 785708-33-0 | Molecular Weight | 377.444 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of APA modulator T4APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts; does not inhibits any of the 404 kinases; predominantly induced CR-APA and UTR-APA; APA modulator T4 exhibits high potency and selectivity for APA modulation, inducing a preference for the use of proximal intronic poly(A) CSs with long intron regions through the PABPN1 pathway; APA modulator T4 is a valuable tool for increasing the understanding of the molecular mechanisms of APA and splicing. |
| Name | APA modulator T4 |
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| Description | APA modulator T4 is a small modulator of alternative polyadenylation (APA) with IC50 of 2.1 uM in reporter assays, modulates endogenous APA via nonkinase-mediated pathways and promotes distal-to-proximal (DtoP) APA usage in multiple transcripts; does not inhibits any of the 404 kinases; predominantly induced CR-APA and UTR-APA; APA modulator T4 exhibits high potency and selectivity for APA modulation, inducing a preference for the use of proximal intronic poly(A) CSs with long intron regions through the PABPN1 pathway; APA modulator T4 is a valuable tool for increasing the understanding of the molecular mechanisms of APA and splicing. |
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| References | References 1. Araki S, et al. Cell Chem Biol. 2018 Sep 26. pii: S2451-9456(18)30301-5. View Related Products by Target Other Targets |
| Molecular Formula | C22H23N3O3 |
|---|---|
| Molecular Weight | 377.444 |