4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one

Modify Date: 2024-01-09 18:54:19

4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one Structure
4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one structure
Common Name 4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one
CAS Number 809234-33-1 Molecular Weight 226.61
Density N/A Boiling Point N/A
Molecular Formula C10H7ClO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one


DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells[1].

 Names

Name 4-(chloromethyl)-5,7-dihydroxychromen-2-one
Synonym More Synonyms

  Biological Activity

Description DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells[1].
Related Catalog
Target

DNA polymerase[1]

In Vivo DNA polymerase-IN-1 (compound 2d)
References

[1]. Bruna-Haupt EF, et al. Synthesis of Structurally Related Coumarin Derivatives as Antiproliferative Agents. ACS Omega. 2023 Jul 13;8(29):26479-26496.  

 Chemical & Physical Properties

Molecular Formula C10H7ClO4
Molecular Weight 226.61
Exact Mass 226.00300
PSA 70.67000
LogP 1.94300

 Safety Information

HS Code 2932209090

 Synthetic Route

~96%

4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one Structure

4-(Chloromethyl...

CAS#:809234-33-1

Literature: Karami, Bahador; Kiani, Mahtab Journal of the Chinese Chemical Society, 2014 , vol. 61, # 2 p. 213 - 216

~94%

4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one Structure

4-(Chloromethyl...

CAS#:809234-33-1

Literature: Sharghi, Hashem; Jokar, Mahboubeh Heterocycles, 2007 , vol. 71, # 12 p. 2721 - 2733

~%

4-(Chloromethyl)-5,7-dihydroxy-2H-chroMen-2-one Structure

4-(Chloromethyl...

CAS#:809234-33-1

Literature: Karami, Bahador; Khodabakhshi, Saeed; Eskandari, Khalil Chemical Papers, 2013 , vol. 67, # 11 p. 1474 - 1478

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2H-1-Benzopyran-2-one,4-(chloromethyl)-5,7-dihydroxy
4-(chloromethyl)-5,7-dihydroxy-2H-chromen-2-one
4-chloromethyl-5,7-dihydroxycoumarin
4-(chloromethyl)-5,7-dihydroxy-2H-1-benzopyran-2-one
4-chloromethyl-5-hydroxyumbelliferone
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