Pseudolaric acid B

Modify Date: 2024-01-04 23:58:03

Pseudolaric acid B structure	Common Name	Pseudolaric acid B
	CAS Number	82508-31-4	Molecular Weight	432.464
	Density	1.3±0.1 g/cm3	Boiling Point	613.8±55.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₈O₈	Melting Point	166°C
	MSDS	USA	Flash Point	208.8±25.0 °C
	Symbol	GHS06, GHS08	Signal Word	Danger

Use of Pseudolaric acid B

Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes[1][2][3]. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy[4][5].

Name	pseudolaric acid b
Synonym	More Synonyms

Description	Pseudolaric Acid B is a diterpene isolated from the root of Pseudolarix kaempferi Gorden (pinaceae), has anti-cancer, antifungal, and antifertile activities, and shows immunosuppressive activity on T lymphocytes[1][2][3]. Pseudolaric Acid B inhibits hepatitis B virus (HBV) secretion through apoptosis and cell cycle arrest. Pseudolaric Acid B induces autophagy[4][5].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> HBV Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology
References	[1]. Zhou BN, et al. Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants. Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:219-26. [2]. Wang WC, et al. [Endocrine activity of pseudolaric acids A and B and their effects on sex hormones, prostaglandins, uteri, and fetuses]. Zhongguo Yao Li Xue Bao. 1991 Mar;12(2):187-90. [3]. Wei N, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5. [4]. Yu J, et al. Pseudolaric acid B inhibits the secretion of hepatitis B virus. Oncol Rep. 2017 Jan;37(1):519-525. [5]. Yu J, et al. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death. Oncol Lett. 2016 Mar;11(3):1731-1737.

Description

Related Catalog

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Inflammation/Immunology

References

[1]. Zhou BN, et al. Some progress on the chemistry of natural bioactive terpenoids from Chinese medicinal plants. Mem Inst Oswaldo Cruz. 1991;86 Suppl 2:219-26.

[2]. Wang WC, et al. [Endocrine activity of pseudolaric acids A and B and their effects on sex hormones, prostaglandins, uteri, and fetuses]. Zhongguo Yao Li Xue Bao. 1991 Mar;12(2):187-90.

[3]. Wei N, et al. The immunosuppressive activity of pseudolaric acid B on T lymphocytes in vitro. Phytother Res. 2013 Jul;27(7):980-5.

[4]. Yu J, et al. Pseudolaric acid B inhibits the secretion of hepatitis B virus. Oncol Rep. 2017 Jan;37(1):519-525.

[5]. Yu J, et al. Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death. Oncol Lett. 2016 Mar;11(3):1731-1737.

Density	1.3±0.1 g/cm3
Boiling Point	613.8±55.0 °C at 760 mmHg
Melting Point	166°C
Molecular Formula	C₂₃H₂₈O₈
Molecular Weight	432.464
Flash Point	208.8±25.0 °C
Exact Mass	432.178406
PSA	116.20000
LogP	2.78
Appearance of Characters	white to off-white
Vapour Pressure	0.0±3.8 mmHg at 25°C
Index of Refraction	1.565
Storage condition	2-8°C
Water Solubility	methanol: soluble1mg/mL, clear, colorless

Pseudolaric acid B MSDS(Chinese)

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H361
Precautionary Statements	P281-P301 + P310
Hazard Codes	T
Risk Phrases	25-62
Safety Phrases	36/37-45-24/25
RIDADR	UN 2811 6.1 / PGIII

(1R,7S,8S,9S)-7...

CAS#:1000669-90-8

3-iodo-2-methyl...

CAS#:128836-43-1

~62%

Pseudolaric acid B

CAS#:82508-31-4

Literature: Trost, Barry M.; Waser, Jerome; Meyer, Arndt Journal of the American Chemical Society, 2008 , vol. 130, # 48 p. 16424 - 16434

methyl (3R,4R,4...

CAS#:457622-28-5

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098

N/A

CAS#:457622-29-6

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098

methyl (3S,4R,4...

CAS#:457622-27-4

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098

methyl (3S,4R,4...

CAS#:457622-33-2

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098

methyl (3R,4R,4...

CAS#:457622-30-9

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098

methyl (3R,4R,4...

CAS#:457622-31-0

Pseudolaric acid B

CAS#:82508-31-4

Literature: Tetrahedron Letters, , vol. 43, # 22 p. 4095 - 4098

Precursor 6
CAS#:1000669-90-8 (1R,7S,8S,9S)-7... CAS#:128836-43-1 3-iodo-2-methyl... CAS#:457622-27-4 methyl (3S,4R,4... CAS#:457622-33-2 methyl (3S,4R,4...
CAS#:457622-30-9 methyl (3R,4R,4... CAS#:457622-31-0 methyl (3R,4R,4...
DownStream 0

Newly discovered angiogenesis inhibitors and their mechanisms of action.

Acta Pharmacol. Sin. 33(9) , 1103-11, (2012)

In the past decade, the success of angiogenesis inhibitors in clinical contexts has established the antiangiogenic strategy as an important part of cancer therapy. During that time period, we have dis...

Bcl-2 family proteins were involved in pseudolaric acid B-induced autophagy in murine fibrosarcoma L929 cells.

J. Pharmacol. Sci. 107(3) , 295-302, (2008)

Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treat...

In vitro synergy of pseudolaric acid B and fluconazole against clinical isolates of Candida albicans.

Mycoses 54(5) , e400-6, (2011)

Candida albicans is the most common fungal pathogen in humans. The emergence of resistance to azole antifungals has raised the issue of using such antifungals in combination to optimise therapeutic ou...

(2E,4E)-5-[(1R,7S,8R,9R)-4,7-Bis(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methylpenta-2,4-dienoic acid

(2E,4E)-5-[(1S,7S,8S,9R)-7-Acetoxy-4-(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methyl-2,4-pentadienoic acid

1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic acid, 4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-, 7-methyl ester, (3R,4S,4aS,9aS)-

(2E,4E)-5-[(1R,7S,8R,9R)-4,7-Bis(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methyl-2,4-pentadienoic acid

1H-4,9a-Ethanocyclohepta[c]pyran-4a,7(5H)-dicarboxylic acid, 3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,6,9-tetrahydro-3-methyl-1-oxo-, 4a,7-dimethyl ester, (3R,4R,4aS,9aR)-

PLAB

(2E,4E)-5-[(1S,7S,8S,9R)-7-Acetoxy-4-(methoxycarbonyl)-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-en-9-yl]-2-methylpenta-2,4-dienoic acid

PseudolaricAcidB

Pseudolarix acid B

BioBioPha
China
Product Name: Pseudolaric acid B
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pseudolaric acid B
Price: ￥408.0/20mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Pseudolaric Acid B
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pseudolaric acid B
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Get all suppliers and price by the below link:

Pseudolaric acid B suppliers

Pseudolaric acid B price

Pseudolaric acid B

Use of Pseudolaric acid B

Names

Pseudolaric acid B Biological Activity

Chemical & Physical Properties

MSDS

Safety Information

Synthetic Route

Precursor & DownStream

Articles22

Synonyms