Pseudolaric acid B
Pseudolaric acid B structure
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Common Name | Pseudolaric acid B | ||
|---|---|---|---|---|
| CAS Number | 82508-31-4 | Molecular Weight | 432.464 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 613.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C23H28O8 | Melting Point | 166°C | |
| MSDS | USA | Flash Point | 208.8±25.0 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Newly discovered angiogenesis inhibitors and their mechanisms of action.
Acta Pharmacol. Sin. 33(9) , 1103-11, (2012) In the past decade, the success of angiogenesis inhibitors in clinical contexts has established the antiangiogenic strategy as an important part of cancer therapy. During that time period, we have discovered and reported 17 compounds that exert potent inhibit... |
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Bcl-2 family proteins were involved in pseudolaric acid B-induced autophagy in murine fibrosarcoma L929 cells.
J. Pharmacol. Sci. 107(3) , 295-302, (2008) Pseudolaric acid B (PAB) exerted cytostatic activity on murine fibrosarcoma L929 cells. The cytostatic mechanism of PAB on L929 cells was investigated in this paper. At 36 h, after 80 microM PAB treatment, the inhibitory ratio was 65.37 +/- 4.12%, and the MDC... |
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In vitro synergy of pseudolaric acid B and fluconazole against clinical isolates of Candida albicans.
Mycoses 54(5) , e400-6, (2011) Candida albicans is the most common fungal pathogen in humans. The emergence of resistance to azole antifungals has raised the issue of using such antifungals in combination to optimise therapeutic outcome. The objective of this study was to evaluate in vitro... |
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Preparative isolation of pseudolaric acids A and B, and their glucosides from the root bark of Pseudolarix kaempferi using high-speed counter-current chromatography.
J. Sep. Sci. 32(2) , 309-13, (2009) In order to provide the chemical markers for the quality control of herbal medicines, four diterpenoids, pseudolaric acids A and B (PAA and PAB), and their glucosides were isolated from the methanol extract of the Chinese herb Pseudolarix kaempferi using high... |
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Effects of PLAB on apoptosis and Smad signal pathway of hypertrophic scar fibroblasts.
J. Asian Nat. Prod. Res. 10(1-2) , 147-57, (2008) Pseudolaric acid-B (PLAB), a diterpene acid, was isolated from the root and trunk barks of Pseudolarix kaempferi. It has shown antifungal and anti-fertility effects and cytotoxic activities in previous studies. Our goals are to study the effects of PLAB on ce... |
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Topical application of Pseudolaric acid B improve DNFB-induced contact hypersensitivity via regulating the balance of Th1/Th17/Treg cell subsets.
Eur. J. Pharm. Sci. 45(5) , 668-76, (2012) Pseudolaric acid B (PAB) is a novel diterpenoid, isolated from Pseudolarix kaempferi Gorden, which roots are widely used to treat inflammatory and microbial skin diseases for centuries, but the underlying mechanism remains elusive. To address the immunoregula... |
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Angiogenesis inhibition and cell cycle arrest induced by treatment with Pseudolarix acid B alone or combined with 5-fluorouracil.
Acta Biochim. Biophys. Sin. (Shanghai) 44(6) , 490-502, (2012) Angiogenesis inhibitors combined with chemotherapeutic drugs have significant efficacy in the treatment of a variety of cancers. Pseudolarix acid B (PAB) is a traditional pregnancy-terminating agent, which has previously been shown to reduce tumor growth and ... |
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Total synthesis of (-)-pseudolaric acid B.
J. Am. Chem. Soc. 130(48) , 16424-34, (2008) We report a full account of our work toward the total synthesis of pseudolaric acid B (1a), a diterpene acid isolated from the bark of Pseudolarix kaempferi Gordon (pinaceae). Compound 1a is an antifungal and antifertility agent. Furthermore, its capacity for... |
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[Cycle arrest of prostate carcinoma DU-145 cells induced by pseudolaric acid B].
Zhongguo Zhong Yao Za Zhi 37(22) , 3467-71, (2012) To study the effect of pseudolaric acid B (PLAB) on cell proliferation and cycle of human prostate carcinoma DU-145 cells. method: Its inhibitory effect on the cell growth was measured by MTT method. Characteristics of cell death were determined by Hoechest 3... |
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[Effects of pseudolaric acid B on apoptosis of bladder cancer cell 5637].
Zhongguo Zhong Yao Za Zhi 36(24) , 3535-8, (2011) To investigate the apoptosis of bladder cancer cell 5637 induced by pseudolaric acid B in vitro and its mechanism.The cell proliferation was detected by MTT assay;the cell cycle was measured by flow cytometry; the cell apoptosis was observed by flow cytometry... |