Cetirizine

Modify Date: 2024-01-02 11:46:58

Cetirizine Structure
Cetirizine structure
Common Name Cetirizine
CAS Number 83881-51-0 Molecular Weight 388.888
Density 1.2±0.1 g/cm3 Boiling Point 542.1±45.0 °C at 760 mmHg
Molecular Formula C21H25ClN2O3 Melting Point 110-115°C
MSDS N/A Flash Point 281.6±28.7 °C

 Use of Cetirizine


Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. IC50 value:Target: Histamine H1 receptorCetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. From Wikipedia.

 Names

Name cetirizine
Synonym More Synonyms

 Cetirizine Biological Activity

Description Cetirizine, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. IC50 value:Target: Histamine H1 receptorCetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect common with older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form. From Wikipedia.
Related Catalog
References

[1]. Hair PI, Scott LJ. Levocetirizine: a review of its use in the management of allergic rhinitis and skin allergies. Drugs. 2006;66(7):973-96.

[2]. Day JH, Ellis AK, Rafeiro E. Levocetirizine: a new selective H1 receptor antagonist for use in allergic disorders. Drugs Today (Barc). 2004 May;40(5):415-21.

[3]. Namazi MR. Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders. Int Immunopharmacol. 2004 Mar;4(3):349-53.

[4]. Curran MP, Scott LJ, Perry CM. Cetirizine: a review of its use in allergic disorders. Drugs. 2004;64(5):523-61.

[5]. Portnoy JM, Dinakar C. Review of cetirizine hydrochloride for the treatment of allergic disorders. Expert Opin Pharmacother. 2004 Jan;5(1):125-35.

[6]. Huang L, et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-κB signaling. Pharmacol Res. 2017 Aug 31. pii: S1043-6618(17)30796-X.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 542.1±45.0 °C at 760 mmHg
Melting Point 110-115°C
Molecular Formula C21H25ClN2O3
Molecular Weight 388.888
Flash Point 281.6±28.7 °C
Exact Mass 388.155365
PSA 53.01000
LogP 2.16
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.589
Storage condition 2-8℃
Water Solubility 101 mg/L

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AG0977500
CHEMICAL NAME :
Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)et hoxy)-
CAS REGISTRY NUMBER :
83881-51-0
LAST UPDATED :
199606
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C21-H25-Cl-N2-O3
MOLECULAR WEIGHT :
388.93

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
116 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4525358

 Safety Information

Hazard Codes Xn
Risk Phrases R22
WGK Germany 3
RTECS AG0977500
HS Code 2933599090

 Synthetic Route

~84%

Cetirizine Structure

Cetirizine

CAS#:83881-51-0

Literature: A/S GEA Farmaceutisk Fabrik Patent: EP1157016 B1, 2003 ; Location in patent: Page/Page column 5 ;

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Cetirizine Structure

Cetirizine

CAS#:83881-51-0

Literature: US2005/20608 A1, ; Page 5 ;

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Cetirizine Structure

Cetirizine

CAS#:83881-51-0

Literature: Tao; Yong; Karimian; Khashayar; Tam; Tim Fat Patent: US6046332 A1, 2000 ;

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Cetirizine Structure

Cetirizine

CAS#:83881-51-0

Literature: WO2004/103982 A1, ; Page 15-16 ;

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Cetirizine Structure

Cetirizine

CAS#:83881-51-0

Literature: WO2004/103982 A1, ; Page 16 ;

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Cetirizine Structure

Cetirizine

CAS#:83881-51-0

Literature: US2009/30205 A1, ; Page/Page column 4; 5 ;

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
(2-{4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid
Reactine
CERTIRIZINE 2HCL
Zirtek
acetic acid, [2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
Cetirizine
Ceterizine
[(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethyl)oxy]acetic acid
Acetic acid, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-
vidix
P-071
MFCD00800721
(±)-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid
Cetrizinehydrochloride
Formistin
(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
UNII:YO7261ME24
Zyrlex
(±)-[2-[4-(p-Chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]acetic Acid
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  • DC Chemicals Limited
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  • Product Name: Cetirizine
  • Price: $100.0/200mg $200.0/500mg $400.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


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