Cordycepin

Modify Date: 2025-08-21 07:48:49

Cordycepin structure	Common Name	Cordycepin
	CAS Number	73-03-0	Molecular Weight	251.242
	Density	1.9±0.1 g/cm3	Boiling Point	627.2±65.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₁₃N₅O₃	Melting Point	225-229ºC
	MSDS	Chinese USA	Flash Point	333.1±34.3 °C
	Symbol	GHS06	Signal Word	Danger

Use of Cordycepin

Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.

Name	Cordycepin
Synonym	More Synonyms

Description	Cordycepin, which is a nucleoside derivative isolated from Cordyceps, inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Natural Products >> Alkaloid Research Areas >> Cancer Research Areas >> Inflammation/Immunology
Target	MMP-1 MMP-3
In Vitro	Cordycepin is a potent inhibitor of IL-1β-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs. The effect of Cordycepin on cellular toxicity of RASFs is assessed using MTT assay. Treatment of RASFs with Cordycepin (50 μM or 100 μM) for 24 h does not cause any significant change in cell viability. However, cell viability is slightly decreased when cells are incubated with 100 μM Cordycepin for 48 h[1].
Cell Assay	RASFs (2×104 cells/well) are treated with various concentrations of Cordycepin (50 μM or 100 μM). After incubation for 1 h, 12 h and 24 h, cells are washed twice with PBS, MTT (0.5 mg/mL PBS) is added to each well and incubated at 37°C for 30 min. Formazan crystals formed are dissolved by adding DMSO (100 μL/well) and the absorbance is read at 570 nm using a microplate reader[1].
References	[1]. Noh EM, et al. Cordycepin inhibits IL-1beta-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford). 2009 Jan;48(1):45-8.

Density	1.9±0.1 g/cm3
Boiling Point	627.2±65.0 °C at 760 mmHg
Melting Point	225-229ºC
Molecular Formula	C₁₀H₁₃N₅O₃
Molecular Weight	251.242
Flash Point	333.1±34.3 °C
Exact Mass	251.101837
PSA	119.31000
LogP	-0.41
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.863
InChIKey	OFEZSBMBBKLLBJ-BAJZRUMYSA-N
SMILES	Nc1ncnc2c1ncn2C1OC(CO)CC1O
Storage condition	−20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AU7358610

CHEMICAL NAME :: Adenosine, 3'-deoxy-

CAS REGISTRY NUMBER :: 73-03-0

BEILSTEIN REFERENCE NO. :: 0035194

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H13-N5-O3

MOLECULAR WEIGHT :: 251.28

WISWESSER LINE NOTATION :: T56 BN DN FN HNJ IZ D- BT5OTJ CQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 80 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 20 mg/L

REFERENCE :: JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 35,119,1982

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes	T:Toxic
Risk Phrases	R25;R36/37/38
Safety Phrases	S26-S45
RIDADR	UN 2811
WGK Germany	3
RTECS	AU7358610
HS Code	29349990

Precursor 6
CAS#:2627-64-7 2′,3′-Anhydroad... CAS#:116285-72-4 9-[2,5-bis-O-(t... CAS#:71196-28-6 ((2S,4R,5R)-4-a... CAS#:51763-58-7 (2R,3R,5S)-2-(6...
CAS#:4395-38-4 N6,2',5'-triben... CAS#:58-61-7 Adenosine
DownStream 7
CAS#:4097-22-7 2',3'-Dideoxyad... CAS#:189887-77-2 [(2R,3R,5S)-2-(... CAS#:207347-42-0 N6-Bz-5'-O-DMTr... CAS#:17434-81-0 CORDYCEPIN-5-MO...
CAS#:110143-10-7 LODENOSINE CAS#:76902-49-3 N6-BENZOYL-3'-D... CAS#:84138-86-3 N6-BENZOYL-5'-O...

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells.

Environ. Toxicol. Pharmacol. 38(1) , 239-50, (2014)

Cordycepin, an active ingredient of the insect fungus Cordyceps spp., shows strong antioxidant and anticancer activities. Several molecular mechanisms have been attributed to its inhibitory effects on...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Anti-HCV activity of the Chinese medicinal fungusCordyceps militaris

Biochem. Biophys. Res. Commun. 447(2) , 341-5, (2014)

• Cordyceps militaris (CM) had a moderate anti-HCV activity for RNA replication. • Cordycepin is a responsible compound for the anti-HCV activity of CM. • CM would be a useful anti-HCV agent in combin...

Name: Cytotoxicity against human BXPC-3 cells assessed as cell death incubated for 72 hrs b...
Source: ChEMBL
Target: BXPC-3
External Id: CHEMBL5238794

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: Cytotoxicity against human MCF7 cells assessed as maximum cell growth inhibition incu...
Source: ChEMBL
Target: MCF7
External Id: CHEMBL5238793

Name: Cytotoxicity against human HT-29 cells assessed as cell death incubated for 72 hrs by...
Source: ChEMBL
Target: HT-29
External Id: CHEMBL5238796

Name: Cytotoxicity against human BXPC-3 cells assessed as maximum cell growth inhibition in...
Source: ChEMBL
Target: BXPC-3
External Id: CHEMBL5238795

Name: Cytotoxicity against human HepG2 cells assessed as cell death incubated for 72 hrs by...
Source: ChEMBL
Target: HepG2
External Id: CHEMBL5238790

Name: Cytotoxicity against human HS 445 cells assessed as maximum cell growth inhibition in...
Source: ChEMBL
Target: N/A
External Id: CHEMBL5238789

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytotoxicity against human MCF7 cells assessed as cell death incubated for 72 hrs by ...
Source: ChEMBL
Target: MCF7
External Id: CHEMBL5238792

Name: Cytotoxicity against human HepG2 cells assessed as maximum cell growth inhibition inc...
Source: ChEMBL
Target: HepG2
External Id: CHEMBL5238791

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Adenine cordyceposide

EINECS 200-791-4

Adenosine,3-deoxy

Cordycepine

MFCD00037998

Cordycepin

Cordyceps fungus powder

cordycepin crystalline

3'-Deoxyadenosine

(-)-cordycepin

3'-Deoxy-D-adenosine

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Cordycepin

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