Boc-C14-COOH
Modify Date: 2024-01-02 18:04:48
Boc-C14-COOH structure
|
Common Name | Boc-C14-COOH | ||
|---|---|---|---|---|
| CAS Number | 843666-27-3 | Molecular Weight | 341.50500 | |
| Density | 0.959±0.06 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H38O4 | Melting Point | 58.0-62.0°C | |
| MSDS | N/A | Flash Point | N/A | |
Use of Boc-C14-COOHBoc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
| Name | 16-[(2-methylpropan-2-yl)oxy]-16-oxohexadecanoate |
|---|---|
| Synonym | More Synonyms |
| Description | Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 0.959±0.06 g/cm3 |
|---|---|
| Melting Point | 58.0-62.0°C |
| Molecular Formula | C20H38O4 |
| Molecular Weight | 341.50500 |
| Exact Mass | 341.26900 |
| PSA | 66.43000 |
| LogP | 4.53940 |
| Water Solubility | Insuluble (2.9E-3 g/L) (25 ºC) |
| HS Code | 2918990090 |
|---|
|
~33%
Boc-C14-COOH CAS#:843666-27-3 |
| Literature: NOVO NORDISK A/S Patent: WO2007/128817 A2, 2007 ; Location in patent: Page/Page column 81 ; |
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| mono-tert-butyl hexadecandioate |
| hexadecanedioic acid mono-tert-butyl ester |
| tert-Butyl hydrogen hexadecanedioate |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Boc-C14-COOH
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- Shanghai Jizhi Biochemical Technology Co., Ltd
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- China
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- Nanjing Peptide Biotech Ltd
- China
- Product Name: tert-Butyl Hydrogen Hexadecanedioate
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- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 16-(tert-Butoxy)-16-oxopalmitic acid, tert-Butyl 15-carboxypentadecanoate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
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- Email: enquiry@dycnchem.com
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