Boc-C14-COOH

Modify Date: 2024-01-02 18:04:48

Boc-C14-COOH Structure
Boc-C14-COOH structure
 Common Name Boc-C14-COOH
CAS Number 843666-27-3 Molecular Weight 341.50500
Density 0.959±0.06 g/cm3 Boiling Point N/A
Molecular Formula C20H38O4 Melting Point 58.0-62.0°C
MSDS N/A Flash Point N/A

 Use of Boc-C14-COOH


Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

 Names

Name 16-[(2-methylpropan-2-yl)oxy]-16-oxohexadecanoate
Synonym More Synonyms

 Boc-C14-COOH Biological Activity

Description Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog
Target

Non-cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

 Chemical & Physical Properties

Density 0.959±0.06 g/cm3
Melting Point 58.0-62.0°C
Molecular Formula C20H38O4
Molecular Weight 341.50500
Exact Mass 341.26900
PSA 66.43000
LogP 4.53940
Water Solubility Insuluble (2.9E-3 g/L) (25 ºC)

 Safety Information

HS Code 2918990090

 Synthetic Route

Hexadecanedioic acid structure

Hexadecanedioic acid

CAS#:505-54-4

1,1-Di-tert-butoxy-N,N-dimethylmethanamine structure

1,1-Di-tert-but...

CAS#:36805-97-7

~33%

Boc-C14-COOH Structure

Boc-C14-COOH

CAS#:843666-27-3

Literature: NOVO NORDISK A/S Patent: WO2007/128817 A2, 2007 ; Location in patent: Page/Page column 81 ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

mono-tert-butyl hexadecandioate
hexadecanedioic acid mono-tert-butyl ester
tert-Butyl hydrogen hexadecanedioate
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Chemsrc provides Boc-C14-COOH(CAS#:843666-27-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Boc-C14-COOH are included as well.>> amp version: Boc-C14-COOH

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