Boc-NH-PEG3-CH2COOH

Modify Date: 2024-01-06 15:40:55

Boc-NH-PEG3-CH2COOH Structure
Boc-NH-PEG3-CH2COOH structure
Common Name Boc-NH-PEG3-CH2COOH
CAS Number 462100-06-7 Molecular Weight 307.34000
Density 1.141±0.06 g/cm3 Boiling Point 460.1±35.0°C at 760 mmHg
Molecular Formula C13H25NO7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Boc-NH-PEG3-CH2COOH


Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

 Names

Name Boc-11-amino-3,6,9-trioxaundecanoic acid
Synonym More Synonyms

 Boc-NH-PEG3-CH2COOH Biological Activity

Description Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Vollmer S, et al. Design, Synthesis, and Biological Evaluation of MEK PROTACs. J Med Chem. 2020 Jan 9;63(1):157-162.

 Chemical & Physical Properties

Density 1.141±0.06 g/cm3
Boiling Point 460.1±35.0°C at 760 mmHg
Molecular Formula C13H25NO7
Molecular Weight 307.34000
Exact Mass 307.16300
PSA 103.32000
LogP 1.03640
Water Solubility Soluble (68 g/L) (25 ºC)

 Synonyms

Boc-NH-PEG3-COOH
{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethoxy}-acetic acid
2-[2-{2-(N-tert-butoxycarbonyl)aminoethoxy}ethoxy]ethoxyacetic acid
2,2-dimethyl-4-oxo-3,8,11,14-tetraoxa-5-azohexadecan-16-oic acid
11-N-t-Boc-amino-3,6,9-trioxaundecanoic acid
Boc-NH-mini-PEG-COOH
5,8,11-Trioxa-2-azatridecanedioic acid 1-(1,1-dimethylethyl) ester
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