ICI 162,846

Modify Date: 2024-04-01 21:37:47

ICI 162,846 structure	Common Name	ICI 162,846
	CAS Number	84545-30-2	Molecular Weight	306.29
	Density	1.45g/cm3	Boiling Point	500.4ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₇F₃N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	256.5ºC

Use of ICI 162,846

ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU[1][2].

Name	5-[3-[[N'-(2,2,2-trifluoroethyl)carbamimidoyl]amino]pyrazol-1-yl]pentanamide
Synonym	More Synonyms

Description	ICI 162846 is an orally active antagonist of H2 receptor. ICI 162846 inhibits acid production accompanied by an increase in the secretion of histamine in chronic duodenal ulcer (CDU) models. ICI 162846 is effective in preventing CDU[1][2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
Target	H2 Receptor
References	[1]. Wilson JA, et al. Inhibition of human gastric secretion by ICI 162,846--a new histamine H2-receptor antagonist. Br J Clin Pharmacol. 1986 Jun;21(6):685-9. [2]. Gompertz RH, et al. Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions. 1991 May;33(1-2):161-3.

Density	1.45g/cm3
Boiling Point	500.4ºC at 760 mmHg
Molecular Formula	C₁₁H₁₇F₃N₆O
Molecular Weight	306.29
Flash Point	256.5ºC
Exact Mass	306.14200
PSA	108.82000
LogP	2.30120
Index of Refraction	1.563

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ7889000

CHEMICAL NAME :: 1H-Pyrazole-1-pentanamide, 3-((imino((2,2,2-trifluoroethyl)amino)methyl)amino)-

CAS REGISTRY NUMBER :: 84545-30-2

LAST UPDATED :: 199507

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H17-F3-N6-O

MOLECULAR WEIGHT :: 306.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 365 gm/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,366,1987

Tocris-0833

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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
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