Oleyloxyethyl Phosphorylcholine

Modify Date: 2024-01-02 18:33:53

Oleyloxyethyl Phosphorylcholine Structure
Oleyloxyethyl Phosphorylcholine structure
Common Name Oleyloxyethyl Phosphorylcholine
CAS Number 84601-19-4 Molecular Weight 477.66
Density N/A Boiling Point N/A
Molecular Formula C25H52NO5P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Oleyloxyethyl Phosphorylcholine


(Z)-Oleyloxyethyl phosphorylcholine ((Z)-OPC) is an isomer of Oleyloxyethyl phosphorylcholine (OPC). Oleyloxyethyl phosphorylcholine is an inhibitor of secreted Phospholipase A2 (sPLA2), which is involved in the biosynthesis of proinflammatory lipid media. Oleyloxyethyl phosphorylcholine can be used to study inflammatory diseases. Oleyloxyethyl phosphorylcholine also modified the red blood membrane and was used to bind the oxygen-carrying liquid perfluorocarbons as an antivenom agent to reduce toxin-induced hemolysis[1][2].

 Names

Name oleyloxyethyl phosphorylcholine
Synonym More Synonyms

 Oleyloxyethyl Phosphorylcholine Biological Activity

Description (Z)-Oleyloxyethyl phosphorylcholine ((Z)-OPC) is an isomer of Oleyloxyethyl phosphorylcholine (OPC). Oleyloxyethyl phosphorylcholine is an inhibitor of secreted Phospholipase A2 (sPLA2), which is involved in the biosynthesis of proinflammatory lipid media. Oleyloxyethyl phosphorylcholine can be used to study inflammatory diseases. Oleyloxyethyl phosphorylcholine also modified the red blood membrane and was used to bind the oxygen-carrying liquid perfluorocarbons as an antivenom agent to reduce toxin-induced hemolysis[1][2].
Related Catalog
Target

sPLA2

References

[1]. Hope WC, et al. Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2. Agents Actions. 1993;39 Spec No:C39-42.  

[2]. Yang Zhe, et al. Oxygen-carrying bionic nano antidote and its preparation method and application in preparation of anti snake venom drug. China, CN113509488 A. 2021-10-19.

 Chemical & Physical Properties

Molecular Formula C25H52NO5P
Molecular Weight 477.66
Exact Mass 491.337585
PSA 94.70000
LogP 3.87
Storage condition ?20°C

 MSDS

Version 1.2
Regulation (EC) No 1907/2006

1 - Product and Company Information

Product NamePHOSPHORYLCHOLINE, OLEOYLOXYETHYL ESTER

2 - Hazards Identification

3 - Composition/Information on Ingredients

Product NameCAS #EC noAnnex I
Index Number
PHOSPHORYLCHOLINE, OLEOYLOXYETHYL 84601-19-4 NoneNone
ESTER
FormulaC25H52NO5P
Molecular Weight 477,7000 AMU

4 - First Aid Measures

AFTER INHALATION
If inhaled, remove to fresh air. If not breathing give
artificial respiration. If breathing is difficult, give oxygen.
AFTER SKIN CONTACT
In case of contact, immediately wash skin with soap and copious
amounts of water.
AFTER EYE CONTACT
In case of contact, immediately flush eyes with copious amounts
of water for at least 15 minutes.
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

5 - Fire Fighting Measures

EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
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SPECIAL RISKS
Specific Hazard(s): Emits toxic fumes under fire conditions.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

6 - Accidental Release Measures

PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.

7 - Handling and Storage

STORAGE
Store at -20°C

8 - Exposure Controls / Personal Protection

ENGINEERING CONTROLS
Safety shower and eye bath. Mechanical exhaust required.
GENERAL HYGIENE MEASURES
Wash contaminated clothing before reuse.
PERSONAL PROTECTIVE EQUIPMENT
Respiratory Protection: Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US)
or CEN (EU). Respiratory protection is not required. Where
protection from nuisance levels of dusts are desired, use type N95
(US) or type P1 (EN 143) dust masks.
Hand Protection: Compatible chemical-resistant gloves.
Eye Protection: Chemical safety goggles.

9 - Physical and Chemical Properties

AppearancePhysical State: Solid
PropertyValueAt Temperature or Pressure
pHN/A
BP/BP RangeN/A
MP/MP RangeN/A
Flash PointN/A
FlammabilityN/A
Autoignition TempN/A
Oxidizing PropertiesN/A
Explosive PropertiesN/A
Explosion LimitsN/A
Vapor PressureN/A
Partition CoefficientN/A
ViscosityN/A
Vapor DensityN/A
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Saturated Vapor Conc. N/A
Evaporation RateN/A
Bulk DensityN/A
Decomposition Temp.N/A
Solvent ContentN/A
Water ContentN/A
Surface TensionN/A
ConductivityN/A
Miscellaneous DataN/A
SolubilityN/A

10 - Stability and Reactivity

STABILITY
Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Phosphorous oxides.

11 - Toxicological Information

SIGNS AND SYMPTOMS OF EXPOSURE
To the best of our knowledge, the chemical, physical, and
toxicological properties have not been thoroughly investigated.
ROUTE OF EXPOSURE
Skin Contact: May cause skin irritation.
Eye Contact: May cause eye irritation.
Inhalation: Material may be irritating to mucous membranes and
upper respiratory tract.
Multiple Routes: May be harmful by inhalation, ingestion, or
skin absorption.

12 - Ecological Information

No data available.

13 - Disposal Considerations

SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
regulations.

14 - Transport Information

RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

15 - Regulatory Information

Caution: Substance not yet fully tested (EU).
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COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

16 - Other Information

WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
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SECTION 16 - ADDITIONAL INFORMATION
N/A

 Synonyms

2-[(9Z)-9-Octadecenoyloxy]ethyl 2-(trimethylammonio)ethyl phosphate
Ethanaminium, 2-[[hydroxy[2-[[(9Z)-1-oxo-9-octadecen-1-yl]oxy]ethoxy]phosphinyl]oxy]-N,N,N-trimethyl-, inner salt