AIMP2-DX2-IN-1

Modify Date: 2024-01-10 16:04:14

AIMP2-DX2-IN-1 structure	Common Name	AIMP2-DX2-IN-1
	CAS Number	848256-17-7	Molecular Weight	359.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AIMP2-DX2-IN-1

AIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM[1].

Name	AIMP2-DX2-IN-1

Description	AIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.1063 μM (AIMP2-DX2)[1]
In Vitro	AIMP2-DX2-IN-1 (Compound 35) (0-1 μM, 96 h) shows inhibitory activity against A549 and H460 cells without toxicity for normal cells[1]. AIMP2-DX2-IN-1 showes very poor metabolic stability and good plasma stability in both human and mouse, and CYP inhibition need to be improved[1]. Cell Viability Assay[1] Cell Line: A549, H460 and WI-26 Concentration: 0-1 μM Incubation Time: 96 h Result: Showed inhibitory activities with EC50s of 0.690 ± 0.648 μM and 0.150 ± 0.062 μM against A549 and H460 cells, respectively. And is not active for WI-26.
References	[1]. Lee B, et al. Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors. Bioorg Med Chem Lett. 2022 Jul 13;73:128889.

Molecular Formula	C₂₃H₂₁NO₃
Molecular Weight	359.42