OGT 2115

Modify Date: 2024-01-30 10:57:15

OGT 2115 structure	Common Name	OGT 2115
	CAS Number	853929-59-6	Molecular Weight	495.297
	Density	1.6±0.1 g/cm3	Boiling Point	685.9±55.0 °C at 760 mmHg
	Molecular Formula	C₂₄H₁₆BrFN₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	368.6±31.5 °C

Use of OGT 2115

OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC50 of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity[1][2].

Name	2-[2-[4-[[1-(4-bromophenyl)-3-oxoprop-1-en-2-yl]amino]-3-fluorophenyl]-1,3-benzoxazol-5-yl]acetic acid
Synonym	More Synonyms

Description	OGT 2115 is a potent, cell-permeable and orally active heparanase inhibitor with an IC50 of 0.4 μM. OGT 2115 has anti-angiogenic properties (IC50 of 1 μM). OGT 2115 also inhibits heparan sulfate degradation activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 0.4 μM (Heparanase)[1]
In Vitro	Heparanase InhibitorOGT 2115 can suppress metastasis induced by endoplasmic reticulum (ER) stress in breast cancer cells, although not significantly. However, compared with the control group, the number and rate of migrated cells are significantly reduced following the exposure of the cells to Tunicamycin + OGT 2115. OGT 2115 significantly inhibits the invasion and migration induced by Adriamycin. Furthermore, the MTT assay results show that OGT 2115 does not decrease the anti-proliferative effect of Adriamycin[2].
In Vivo	When administered to mice, OGT 2115 (Compound 12d) shows a plasma concentration of ~10x the heparanase IC50 following oral dosing at 20 mg/kg[1].
References	[1]. [1]Courtney SM, et al. Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. Bioorg Med Chem Lett. 2005 May 2;15(9):2295-9. [2]. Li Y, et al. Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase. Int J Mol Med. 2013 May;31(5):1234-42.

Density	1.6±0.1 g/cm3
Boiling Point	685.9±55.0 °C at 760 mmHg
Molecular Formula	C₂₄H₁₆BrFN₂O₄
Molecular Weight	495.297
Flash Point	368.6±31.5 °C
Exact Mass	494.027740
PSA	92.43000
LogP	6.30
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.710

Hazard Codes	Xi

W-9 hydrochloride

[2-(4-{[(2E)-3-(4-Bromophenyl)prop-2-enoyl]amino}-3-fluorophenyl)-1,3-benzoxazol-5-yl]acetic acid

[2-(4-{[(2E)-3-(4-Bromophenyl)-2-propenoyl]amino}-3-fluorophenyl)-1,3-benzoxazol-5-yl]acetic acid

5-Benzoxazoleacetic acid, 2-[4-[[(2E)-3-(4-bromophenyl)-1-oxo-2-propen-1-yl]amino]-3-fluorophenyl]-

2-2-4-1-(4-Bromophenyl)-3-oxoprop-1-en-2-ylamino-3-fluorophenyl-1,3-benzoxazol-5-ylacetic acid

DC Chemicals Limited
China
Product Name: OGT 2115
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-[4-[[3-(4-Bromophenyl)-1-oxo-2-propenyl]amino]-3-fluorophenyl]-5-benzoxazoleaceticacid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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OGT 2115

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