OBA-09
Modify Date: 2024-01-09 12:11:30
OBA-09 structure
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Common Name | OBA-09 | ||
|---|---|---|---|---|
| CAS Number | 856095-68-6 | Molecular Weight | 208.16800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H8O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of OBA-09OBA-09 is a novel multimodal neuroprotectant oxopropanoyloxy benzoic acid (a salicylic acid/pyruvate ester); shows robust protective effects in the postischemic brain.IC50 value:Target: OBA-09 exhibited antioxidative effects in the postischemic brain, which was evidenced by remarkable reduction of lipid peroxidation and 4-hydroxy-2-nonenal staining in OBA-09-administered animals. Reactive oxygen species generation was markedly suppressed in primary cortical cultures under oxygen-glucose deprivation. More interestingly, OBA-09 was capable of scavenging hydroxyl radical in cell-free assays. High-performance liquid chromatography results demonstrated that OBA-09 was hydrolyzed to salicylic acid and pyruvate with t1/2 = 43 min in serum and 4.2 h in brain parenchyma, indicating that antioxidative function of OBA-09 is executed by itself and also by salicylic acid after the hydrolysis. In addition to antioxidative function, OBA-09 exerts anti-excitotoxic and anti-Zn2+-toxic functions, which might be attributed to attenuation of ATP and nicotinamide adenine dinucleotide depletion and to the suppression of nuclear factor-κB activity induction. Together these results indicate that OBA-09 has a potent therapeutic potential as a multimodal neuroprotectant in the postischemic brain and these effects were conferred by OBA-09 itself and subsequently its hydrolyzed products. |
| Name | Benzoic acid, 2-(1,2-dioxopropoxy) |
|---|---|
| Synonym | More Synonyms |
| Description | OBA-09 is a novel multimodal neuroprotectant oxopropanoyloxy benzoic acid (a salicylic acid/pyruvate ester); shows robust protective effects in the postischemic brain.IC50 value:Target: OBA-09 exhibited antioxidative effects in the postischemic brain, which was evidenced by remarkable reduction of lipid peroxidation and 4-hydroxy-2-nonenal staining in OBA-09-administered animals. Reactive oxygen species generation was markedly suppressed in primary cortical cultures under oxygen-glucose deprivation. More interestingly, OBA-09 was capable of scavenging hydroxyl radical in cell-free assays. High-performance liquid chromatography results demonstrated that OBA-09 was hydrolyzed to salicylic acid and pyruvate with t1/2 = 43 min in serum and 4.2 h in brain parenchyma, indicating that antioxidative function of OBA-09 is executed by itself and also by salicylic acid after the hydrolysis. In addition to antioxidative function, OBA-09 exerts anti-excitotoxic and anti-Zn2+-toxic functions, which might be attributed to attenuation of ATP and nicotinamide adenine dinucleotide depletion and to the suppression of nuclear factor-κB activity induction. Together these results indicate that OBA-09 has a potent therapeutic potential as a multimodal neuroprotectant in the postischemic brain and these effects were conferred by OBA-09 itself and subsequently its hydrolyzed products. |
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| Related Catalog | |
| References |
| Molecular Formula | C10H8O5 |
|---|---|
| Molecular Weight | 208.16800 |
| Exact Mass | 208.03700 |
| PSA | 80.67000 |
| LogP | 0.87920 |
| Storage condition | 2-8℃ |
| OBA-09 HYDRATE |
| Pyruvic acid, salicylic acid ester |
| OBA-09 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: O-Pyruvoylsalicylicacidhydrate
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: OBA-09
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: OBA-09
- Price: $Inquiry/5mg $Inquiry/25mg $Inquiry/100mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: O-Pyruvoylsalicylic acid hydrate
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
Get all suppliers and price by the below link:
Price: $92/10mM*1mLinDMSO
Reference only. check more OBA-09 price