85650-52-8

85650-52-8 structure

Name: Mirtazapine
Chemical Name: Mirtazapine
CAS Number: 85650-52-8
Molecular Formula: C₁₇H₁₉N₃
Molecular Weight: 265.353
Catalog: Biochemical Inhibitor Neuronal Signaling 5-HT Receptor Antagonist
Create Date: 2018-09-08 11:52:06
Modify Date: 2024-01-02 16:31:30
Mirtazapine is a potent tetracyclic antidepressant.Target: 5-HT ReceptorMirtazapine, the novel antidepressant, has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors [1].Mirtazapine appears to have a substantial ameliorating effect on hot flushes and perspiration bouts. It is postulated that the 5-HT(2A) blocking properties of mirtazapine is accounted in the symptomatic relief of hot flushes [2]. After 4-24 weeks of treatment, mirtazapine induced downregulation of platelet alpha(2A)-adrenoceptors (up to 34%) and Galphai proteins (up to 28%), and the upregulation of GRK 2 (up to 30%). Treatment with mirtazapine reversed this abnormality and induced downregulation of alpha(2A)-adrenoceptor/Galphai complex [3].

Name	Mirtazapine
Synonyms	Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl- Zispin (14bR)-2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine 1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO[2.1-A]PYRIDO[2.3-C][2]BENZAZEPINE Mirtazapin 1,2,3,4,10,14B-HEXAHYDRO-2-METHYLPYRAZINO[2,1-A]PYRIDO[2,3-C][2]BENZAZEPINE Remeron ORG-3770 UNII:A051Q2099Q 2-Methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine MIRTAZEPINE 2-Methyl-1,2,3,4,10,14b-hexahydrobenzo[c]pyrazino[1,2-a]pyrido[3,2-f]azepine Mirtazanine Avanza MFCD00865427 MIRTAZAPINE ANHYDRUOS EINECS 288-060-6

Description	Mirtazapine is a potent tetracyclic antidepressant.Target: 5-HT ReceptorMirtazapine, the novel antidepressant, has a dual mode of action. It is a noradrenergic and specific serotonergic antidepressant (NaSSA) that acts by antagonizing the adrenergic alpha2-autoreceptors and alpha2-heteroreceptors as well as by blocking 5-HT2 and 5-HT3 receptors [1].Mirtazapine appears to have a substantial ameliorating effect on hot flushes and perspiration bouts. It is postulated that the 5-HT(2A) blocking properties of mirtazapine is accounted in the symptomatic relief of hot flushes [2]. After 4-24 weeks of treatment, mirtazapine induced downregulation of platelet alpha(2A)-adrenoceptors (up to 34%) and Galphai proteins (up to 28%), and the upregulation of GRK 2 (up to 30%). Treatment with mirtazapine reversed this abnormality and induced downregulation of alpha(2A)-adrenoceptor/Galphai complex [3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
References	[1]. Anttila, S.A. and E.V. Leinonen, A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev, 2001. 7(3): p. 249-64. [2]. Waldinger, M.D., H.H. Berendsen, and D.H. Schweitzer, Treatment of hot flushes with mirtazapine: four case reports. Maturitas, 2000. 36(3): p. 165-8. [3]. Garcia-Sevilla, J.A., et al., Regulation of platelet alpha 2A-adrenoceptors, Gi proteins and receptor kinases in major depression: effects of mirtazapine treatment. Neuropsychopharmacology, 2004. 29(3): p. 580-8.

Density	1.2±0.1 g/cm3
Boiling Point	432.4±45.0 °C at 760 mmHg
Melting Point	114-116ºC
Molecular Formula	C₁₇H₁₉N₃
Molecular Weight	265.353
Flash Point	215.3±28.7 °C
Exact Mass	265.157898
PSA	19.37000
LogP	2.75
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.668
Storage condition	Store at RT
Water Solubility	DMSO: ~8 mg/mL, soluble

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H336
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933990090

61337-89-1

~94%

85650-52-8

Literature: Singer, Claude; Liberman, Anita; Finkelstein, Nina Patent: US2001/51718 A1, 2001 ; Title/Abstract Full Text Show Details Singer, Claude; Liberman, Anita; Finkelstein, Nina Patent: US2003/69417 A1, 2003 ;

1071838-96-4

~82%

85650-52-8

Literature: N.V. ORGANON Patent: WO2008/125578 A2, 2008 ; Location in patent: Page/Page column 16 ;

191546-96-0

~55%

85650-52-8

Literature: N.V. Organon Patent: US2008/255349 A1, 2008 ; Location in patent: Page/Page column 9 ;

1071504-86-3

85650-52-8

Literature: WO2008/125577 A1, ; Page/Page column 22 ;

61337-88-0

85650-52-8

Literature: Organic Preparations and Procedures International, , vol. 39, # 4 p. 399 - 402

6602-54-6

85650-52-8

Literature: Organic Preparations and Procedures International, , vol. 39, # 4 p. 399 - 402

5271-27-2

85650-52-8

Literature: Organic Preparations and Procedures International, , vol. 39, # 4 p. 399 - 402

61338-13-4

85650-52-8

Literature: Organic Preparations and Procedures International, , vol. 39, # 4 p. 399 - 402

Precursor 7
61337-89-1 1071838-96-4 191546-96-0 61337-88-0
6602-54-6 5271-27-2 61338-13-4
DownStream 3
102335-57-9 85650-53-9 61337-86-8

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

119707-74-3	61337-67-5
85650-52-8	102961-72-8
61337-87-9	1215898-55-7
1216678-68-0	191546-97-1
61337-86-8	155172-12-6