IKK-3 Inhibitor structure
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Common Name | IKK-3 Inhibitor | ||
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CAS Number | 862812-98-4 | Molecular Weight | 469.533 | |
Density | 1.4±0.1 g/cm3 | Boiling Point | 744.4±70.0 °C at 760 mmHg | |
Molecular Formula | C22H19N3O5S2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 404.0±35.7 °C |
Use of IKK-3 InhibitorIKK-3 Inhibitor is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. IKK-3 Inhibitor also inhibits IKK2 with an IC50 of 790 nM. |
Name | 5-(5,6-dimethoxybenzimidazol-1-yl)-3-[(2-methylsulfonylphenyl)methoxy]thiophene-2-carbonitrile |
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Synonym | More Synonyms |
Description | IKK-3 Inhibitor is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. IKK-3 Inhibitor also inhibits IKK2 with an IC50 of 790 nM. |
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Related Catalog | |
Target |
TBK1:93 nM (IC50) IKK-ε:469 nM (IC50) IKK2:790 nM (IC50) |
In Vitro | IKK-3 Inhibitor (Compound 1) inhibits TBK1 enzyme with an IC50 of 93 nM, which also translates into good cell potency (72 nM). Moreover, IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB[1]. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM[2]. |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 744.4±70.0 °C at 760 mmHg |
Molecular Formula | C22H19N3O5S2 |
Molecular Weight | 469.533 |
Flash Point | 404.0±35.7 °C |
Exact Mass | 469.076599 |
PSA | 140.06000 |
LogP | 2.57 |
Vapour Pressure | 0.0±2.5 mmHg at 25°C |
Index of Refraction | 1.658 |
Storage condition | 2-8℃ |
HMS3229F19 |
5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(methylsulfonyl)benzyl]oxy}-2-thiophenecarbonitrile |
5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-{[2-(methylsulfonyl)benzyl]oxy}thiophene-2-carbonitrile |
2-Thiophenecarbonitrile, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]- |
IKK-3 Inhibitor |