Boc-Val-Cit-PAB

Modify Date: 2024-01-05 14:49:54

Boc-Val-Cit-PAB Structure
Boc-Val-Cit-PAB structure
Common Name Boc-Val-Cit-PAB
CAS Number 870487-09-5 Molecular Weight 479.570
Density 1.2±0.1 g/cm3 Boiling Point 771.3±60.0 °C at 760 mmHg
Molecular Formula C23H37N5O6 Melting Point N/A
MSDS N/A Flash Point 420.3±32.9 °C

 Use of Boc-Val-Cit-PAB


Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
Synonym More Synonyms

 Boc-Val-Cit-PAB Biological Activity

Description Boc-Val-Cit-PAB is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 771.3±60.0 °C at 760 mmHg
Molecular Formula C23H37N5O6
Molecular Weight 479.570
Flash Point 420.3±32.9 °C
Exact Mass 479.274384
LogP 0.84
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.558
Storage condition 2-8°C

 Synonyms

L-Ornithinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-valyl-N5-carbamoyl-N-[4-(hydroxymethyl)phenyl]-L-ornithinamide
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