N,2-Dihydroxybenzamide

Modify Date: 2025-08-21 12:25:02

N,2-Dihydroxybenzamide Structure
N,2-Dihydroxybenzamide structure
Common Name N,2-Dihydroxybenzamide
CAS Number 89-73-6 Molecular Weight 153.135
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C7H7NO3 Melting Point 177 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 248.9ºC
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Names

Name salicylhydroxamic acid
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 177 °C (dec.)(lit.)
Molecular Formula C7H7NO3
Molecular Weight 153.135
Flash Point 248.9ºC
Exact Mass 153.042587
PSA 69.56000
LogP 0.53
Index of Refraction 1.626
InChIKey HBROZNQEVUILML-UHFFFAOYSA-N
SMILES O=C(NO)c1ccccc1O
Stability Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VO6870000
CHEMICAL NAME :
Salicylohydroxamic acid
CAS REGISTRY NUMBER :
89-73-6
LAST UPDATED :
199412
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C7-H7-N-O3
MOLECULAR WEIGHT :
153.15
WISWESSER LINE NOTATION :
QMVR BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
860 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
1 mmol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1275,1980

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H312-H315-H319-H332-H335-H351
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn:Harmful;
Risk Phrases R40
Safety Phrases S22-S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS VO6870000
HS Code 2924299090

 Synthetic Route

~99%

N,2-Dihydroxybenzamide Structure

N,2-Dihydroxybe...

CAS#:89-73-6

Literature: JANSSEN PHARMACEUTICA N.V. Patent: WO2005/89753 A2, 2005 ; Location in patent: Page/Page column 27 ;

~64%

N,2-Dihydroxybenzamide Structure

N,2-Dihydroxybe...

CAS#:89-73-6

Literature: Lienard, Benoit M.R.; Horsfall, Louise E.; Galleni, Moreno; Frere, Jean-Marie; Schofield, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 964 - 968

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N,2-Dihydroxybenzamide Structure

N,2-Dihydroxybe...

CAS#:89-73-6

Literature: EP1308439 A1, ;

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N,2-Dihydroxybenzamide Structure

N,2-Dihydroxybe...

CAS#:89-73-6

Literature: Oriental Journal of Chemistry, , vol. 28, # 4 p. 1841 - 1844

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N,2-Dihydroxybenzamide Structure

N,2-Dihydroxybe...

CAS#:89-73-6

Literature: Bulletin de la Societe Chimique de France, , p. 2573 - 2580

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N,2-Dihydroxybenzamide Structure

N,2-Dihydroxybe...

CAS#:89-73-6

Literature: Chemicke Listy, , vol. 45, p. 461 Chem.Abstr., , p. 7543

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N,2-Dihydroxybenzamide Structure

N,2-Dihydroxybe...

CAS#:89-73-6

Literature: Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5> 17 II, p. 364 Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5>18 I, p. 378 Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5> 18 I, p. 222

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles28

More Articles
Mechanism of Ni2+ and NiOH+ interaction with hydroxamic acids in SDS: evaluation of the contributions to the equilibrium and rate parameters in the aqueous and micellar phase.

Dalton Trans. 41(24) , 7372-81, (2012)

The equilibria and kinetics (stopped-flow) of the binding of Ni(II) to salicylhydroxamic acid (SHA) and phenylbenzohydroxamic acid (PBHA) have been investigated in aqueous solutions containing SDS mic...

Role of stress-related hormones in plant defence during early infection of the cyst nematode Heterodera schachtii in Arabidopsis.

New Phytol. 207 , 778-89, (2015)

Heterodera schachtii, a plant-parasitic cyst nematode, invades host roots and induces a specific syncytial feeding structure, from which it withdraws all required nutrients, causing severe yield losse...

Development of a two-step high-resolution melting (HRM) analysis for screening sequence variants associated with resistance to the QoIs, benzimidazoles and dicarboximides in airborne inoculum of Botrytis cinerea.

FEMS Microbiol. Lett. 360(2) , 126-31, (2014)

A rapid, high-resolution melting (HRM) analysis protocol was developed to detect sequence variations associated with resistance to the QoIs, benzimidazoles and dicarboximides in Botrytis cinerea airbo...

 N,2-DihydroxybenzamideBioassay

View more

Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
Name: Anti-parasitic activity against diminazene, pentamidine and melaminophenyl arsenical-...
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL3998899
Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
Name: Anti-parasitic activity against bloodstream trypomastigote stage of wild-type Trypano...
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL3998898
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
Name: Cytostatic activity against HEK293T cells after 30 hrs by resazurin based fluorimetri...
Source: ChEMBL
Target: HEK-293T
External Id: CHEMBL3998901
Name: Anti-parasitic activity against bloodstream form of Trypanosoma congolense IL3000 aft...
Source: ChEMBL
Target: Trypanosoma congolense
External Id: CHEMBL3998900
Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
Name: Reduction in oxygen consumption in bloodstream trypomastigote stage of wild-type Tryp...
Source: ChEMBL
Target: Trypanosoma brucei brucei
External Id: CHEMBL3998897
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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 Synonyms

EINECS 201-934-3
N,2-dihydroxybenzamide
MFCD00002110
Salicylhydroxamic acid
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