Salicylamide structure
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Common Name | Salicylamide | ||
|---|---|---|---|---|
| CAS Number | 65-45-2 | Molecular Weight | 137.136 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 279.7±42.0 °C at 760 mmHg | |
| Molecular Formula | C7H7NO2 | Melting Point | 140-144 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 122.9±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of SalicylamideSalicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | salicylamide |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent. |
|---|---|
| Related Catalog | |
| In Vitro | Treatment with salicylamides leads to the bacterial growth inhibition which correlates with the level of inhibition of sulfate reduction[1]. |
| In Vivo | Salicylamide administration decreases the levels of radiosulfate in maternal serum and placenta, and impaires the incorporation of radiosulfate into fetal skeletal GAGs. Salicylamide administration results in a decrease in the calcium content of fetal limb bones, but has no significant effect on maternal serum calcium[2]. Salicylamide administration decreases radiosulfate uptake by maternal serum and liver, fetus and placenta--effects being dose-dependent. Differences in radiosulfate uptake by the fetus and placenta over time, induced by salicylamide, are also significant independently of maternal serum levels of radiosulfate[3]. |
| Animal Admin | Rats: Pregnant rats are fed 25% casein diet with or without 2% salicylamide from day 6 to day 17 or day 19 of gestation. The dams are killed on day 17 or day 19 of gestation, 24 hours following an intramuscular injection of sodium 35S-sulfate[2]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 279.7±42.0 °C at 760 mmHg |
| Melting Point | 140-144 °C(lit.) |
| Molecular Formula | C7H7NO2 |
| Molecular Weight | 137.136 |
| Flash Point | 122.9±27.9 °C |
| Exact Mass | 137.047684 |
| PSA | 63.32000 |
| LogP | 1.11 |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.579 |
| InChIKey | SKZKKFZAGNVIMN-UHFFFAOYSA-N |
| SMILES | NC(=O)c1ccccc1O |
| Storage condition | Refrigerator |
| Stability | Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents. |
| Water Solubility | methanol: 0.1 g/mL, clear | <0.1 g/100 mL at 20 ºC |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22 |
| Safety Phrases | S26-S36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | VN6475000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2924299090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 9 | |
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| DownStream 10 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental... |
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Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.
Antimicrob. Agents Chemother. 53 , 1898-906, (2009) Menstrual toxic shock syndrome is a rare but potentially life-threatening illness manifest through the actions of Staphylococcus aureus toxic shock syndrome toxin 1 (TSST-1). Previous studies have sho... |
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
J. Med. Chem. 54 , 591-602, (2011) Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| ortho-hydroxybenzamide |
| EINECS 200-609-3 |
| 2-hydroxy-benzamide |
| Cidal |
| OHb |
| o-Hydroxybenzamide |
| salicylamide |
| hydroxybenzamide |
| hydroxyphenylamide |
| Benzamide,2-hydroxy |
| 2-Hydroxybenzolcarboxamid |
| Allevin |
| MFCD00007978 |
| 2-hydroxybenzamide |
| Salicylic acid amide |
| 2-Carbamoylphenol |
| Algiamida |
| Algamon |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: How is the water solubility of salicylamide? |
| A: Water solubility of salicylamide: methanol: 0.1 g/mL, clear | <0.1 g/100 mL at 20 ºC. |
| Q: What is the molecular formula of salicylamide? |
| A: Molecular formula of salicylamide is C7H7NO2. |
| Q: What are the upstream materials of salicylamide? |
| A: Related upstream materials(CAS) of salicylamide: 611-20-1;89-95-2;94-67-7;90-02-8;17999-25-6;29579-11-1;2439-77-2;119-36-8;69-72-7. |
| Q: What English synonyms does salicylamide have? |
| A: English synonyms of salicylamide: ortho-hydroxybenzamide, EINECS 200-609-3, 2-hydroxy-benzamide, Cidal, OHb, o-Hydroxybenzamide, salicylamide, hydroxybenzamide, hydroxyphenylamide, Benzamide,2-hydroxy, 2-Hydroxybenzolcarboxamid, Allevin, MFCD00007978, 2-hydroxybenzamide, Salicylic acid amide, 2-Carbamoylphenol, Algiamida, Algamon. |
| Q: What are the uses of salicylamide? |
| A: Main uses of salicylamide: Salicylamide is an inhibitor of microsomal UDP-glucuronosyltransferase. Salicylamide is an analgesic and anti-pyretic agent. |
| Q: What is the polar surface area (PSA) of salicylamide? |
| A: Polar surface area (PSA) of salicylamide is 63.32000. |
| Q: What is the SMILES notation of salicylamide? |
| A: SMILES notation of salicylamide is NC(=O)c1ccccc1O. |
| Q: What is the CAS number of salicylamide? |
| A: CAS number of salicylamide is 65-45-2. |
| Q: What is the InChIKey of salicylamide? |
| A: InChIKey of salicylamide is SKZKKFZAGNVIMN-UHFFFAOYSA-N. |
| Q: What is the molecular weight of salicylamide? |
| A: Molecular weight of salicylamide is 137.136. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |
| Zhongshan Xingrui Chemical Co. , Ltd. |