Biotin-LC-LC-NHS

Modify Date: 2024-01-04 10:15:00

Biotin-LC-LC-NHS Structure
Biotin-LC-LC-NHS structure
Common Name Biotin-LC-LC-NHS
CAS Number 89889-52-1 Molecular Weight 567.698
Density 1.3±0.1 g/cm3 Boiling Point N/A
Molecular Formula C26H41N5O7S Melting Point 147-151ºC
MSDS USA Flash Point N/A

 Use of Biotin-LC-LC-NHS


Biotin-LC-LC-NHS is a SMCC cross-linking reagent that can be used to mark antibody and other small molecules, such as Paclitaxel[1][2].

 Names

Name Succinimidyl-6-[6-(biotinamido)caproyl]caproylate
Synonym More Synonyms

 Biotin-LC-LC-NHS Biological Activity

Description Biotin-LC-LC-NHS is a SMCC cross-linking reagent that can be used to mark antibody and other small molecules, such as Paclitaxel[1][2].
Related Catalog
In Vitro Biotinylation of antibodies is accomplished by the reaction of Biotin-LC-LC-NHS (1 mg/mL in dimethyl formamide) with the protein in aqueous phase pH 7.4. The molar ratio of biotin to antibody in the labeling reaction was 10:1 (the final concentration of biotin was 70 μM) [1].
References

[1]. K Dill, et al. Immunoassays Based on Electrochemical Detection Using Microelectrode Arrays. Biosens Bioelectron. 2004 Nov 1;20(4):736-42.

[2]. Lev G Lis, et al. Synthesis and Biological Evaluation of a Biotinylated Paclitaxel With an Extra-Long Chain Spacer Arm. ACS Med Chem Lett . 2012 Sep 13;3(9):745-748.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Melting Point 147-151ºC
Molecular Formula C26H41N5O7S
Molecular Weight 567.698
Exact Mass 567.272644
PSA 188.31000
LogP -1.83
Index of Refraction 1.579

 Safety Information

RIDADR NONH for all modes of transport
WGK Germany 3

 Synthetic Route

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Biotin-LC-LC-NHS Structure

Biotin-LC-LC-NHS

CAS#:89889-52-1

Literature: US2012/232262 A1, ;

~%

Biotin-LC-LC-NHS Structure

Biotin-LC-LC-NHS

CAS#:89889-52-1

Literature: US2012/232262 A1, ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Articles2

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 Synonyms

(2,5-dioxopyrrolidin-1-yl) 6-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]hexanoate
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[6-[[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]amino]-6-oxohexyl]hexahydro-2-oxo-, (3aS,4S,6aR)-
MFCD00467154
N-{6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl}-6-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)hexanamide