TC-FPR 43

Modify Date: 2024-01-23 19:47:56

TC-FPR 43 structure	Common Name	TC-FPR 43
	CAS Number	903895-98-7	Molecular Weight	384.86
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₁ClN₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TC-FPR 43

FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist[1][2].

Name	FPR Agonist 43

Description	FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	FPR1, FPR2/ALX[1]
In Vitro	FPR Agonist 43 (10-5-107 nM) is actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells[1]. FPR Agonist 43 is also active in the GTPγ binding assay (IC50=207±51 nM)[1]. FPR1 is the preferred receptor for FPR Agonist 43 in in both human neutrophils and possibly also in mouse cells[2]. Cell Viability Assay[1] Cell Line: Chinese hamster ovary (CHO) over-expressing human FPR2/ALX receptors Concentration: 10-5, 10-3, 0.1, 10, 1000, 105, 107 nM Incubation Time: Result: Actively potent in the cAMP assay in FPR2/ALX over-expressing CHO cells (IC50 =11.6±1.9 nM).
References	[1]. Planagumà A, et al. Lack of activity of 15-epi-lipoxin A₄ on FPR2/ALX and CysLT1 receptors in interleukin-8-driven human neutrophil function. Clin Exp Immunol. 2013 Aug;173(2):298-309. [2]. Forsman H, et al. What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin A4? Scand J Immunol. 2011 Sep;74(3):227-234.

Molecular Formula	C₂₀H₂₁ClN₄O₂
Molecular Weight	384.86
Storage condition	2-8℃

Shanghai Nianxing Industrial Co., Ltd
China
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