Antazoline
Antazoline structure
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Common Name | Antazoline | ||
|---|---|---|---|---|
| CAS Number | 91-75-8 | Molecular Weight | 265.353 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 475.5±38.0 °C at 760 mmHg | |
| Molecular Formula | C17H19N3 | Melting Point | 159ºC | |
| MSDS | N/A | Flash Point | 241.4±26.8 °C | |
Use of AntazolineAntazoline is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect[1][2][3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | antazoline |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Antazoline is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
H1 receptor |
| In Vitro | Antazoline shows good inhibitory effect on HBV DNA in the supernatant of HepAD38 and Huh7 cells with the value of EC50 is 2.910 μmol/L and 2.349 μmol/L, respectively[2]. Cell Cytotoxicity Assay[2] Cell Line: HepAD38 cells Concentration: 10μmol/L Incubation Time: 5 days Result: Exhibited no significant cytotoxicity at a concentration of 10μmol/L and had a dose-dependent inhibition of HBV DNA in the supernatant. RT-PCR[2] Cell Line: Huh7 cells Concentration: 30 μmol/L, 10 μmol/L, 3.33 μmol/L, 1.1 μmol/L, 0.370 μmol/L, and 0.123 μmol/L Incubation Time: 4 days Result: Had a significant inhibitory effect on HBV DNA in supernatants in a dose-dependent manner. |
| In Vivo | Antazoline (IP; 0.01 ml/g; 30min) as H1 receptor antagonists diminishes the anticonvulsant activity of carbamazepine and diphenylhydantoin[3]. Animal Model: Swiss mice[3] Dosage: 0.01 mL/g Administration: Antazoline (IP; 0.01 ml/g; 30min) Result: Showed some proconvulsive activity. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 475.5±38.0 °C at 760 mmHg |
| Melting Point | 159ºC |
| Molecular Formula | C17H19N3 |
| Molecular Weight | 265.353 |
| Flash Point | 241.4±26.8 °C |
| Exact Mass | 265.157898 |
| PSA | 27.63000 |
| LogP | 4.39 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.608 |
| InChIKey | REYFJDPCWQRWAA-UHFFFAOYSA-N |
| SMILES | c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1 |
| Storage condition | -20°C |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi |
|---|---|
| Safety Phrases | S22-S24/25 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Antazoline CAS#:91-75-8 |
| Literature: Dash; Kudav; Parihar Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 2 p. 401 - 404 |
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Antazoline CAS#:91-75-8 |
| Literature: Helvetica Chimica Acta, , vol. 33, p. 1386,1403 |
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Antazoline CAS#:91-75-8 |
| Literature: DE847746 , ; DRP/DRBP Org.Chem. US2505248 ; |
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Antazoline CAS#:91-75-8 |
| Literature: DE847746 , ; DRP/DRBP Org.Chem. US2505248 ; |
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Antazoline CAS#:91-75-8 |
| Literature: US2505133 , ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 7 | |
|---|---|
| DownStream 0 | |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Phenazoline |
| Antistin |
| Histostab |
| Fenazolina |
| Phenazolin |
| Histazine |
| N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)phenylamine |
| EINECS 202-094-0 |
| Antastan |
| Antistine |
| Antazoline |
| Imidamine |
| Antihistal |
| N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline |
| N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-anilin |
| MFCD00047013 |
| Antasten |
| benzyl-(4,5-dihydro-1H-imidazol-2-ylmethyl)-phenyl-amine |
| N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-aniline |
| N-(4,5-dihydro-1H-imidazol-2-ylmethyl)-N-(phenylmethyl)aniline |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of antazoline? |
| A: Molecular weight of antazoline is 265.353. |
| Q: What is the InChIKey of antazoline? |
| A: InChIKey of antazoline is REYFJDPCWQRWAA-UHFFFAOYSA-N. |
| Q: What are the upstream materials of antazoline? |
| A: Related upstream materials(CAS) of antazoline: 36271-19-9;107-15-3;13338-49-3;23582-63-0;409111-05-3;501-62-2;100-44-7. |
| Q: What is the polar surface area (PSA) of antazoline? |
| A: Polar surface area (PSA) of antazoline is 27.63000. |
| Q: What is the molecular formula of antazoline? |
| A: Molecular formula of antazoline is C17H19N3. |
| Q: What is the LogP of antazoline? |
| A: LogP of antazoline is 4.39. |
| Q: What are the uses of antazoline? |
| A: Main uses of antazoline: Antazoline is an H1 receptor antagonist that affects the activity of the central nervous system, has a potent antiarrhythmic effect[1][2][3]. |
| Q: What is the safety information for antazoline? |
| A: Safety information for antazoline: S22-S24/25. |
| Q: What is the English name of antazoline? |
| A: The English name of antazoline is antazoline. |
| Q: What is the melting point of antazoline? |
| A: Melting point of antazoline is 159ºC. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |