Thiochrome

Modify Date: 2024-01-02 20:51:41

Thiochrome Structure
Thiochrome structure
Common Name Thiochrome
CAS Number 92-35-3 Molecular Weight 262.33100
Density 1.49g/cm3 Boiling Point 462.6ºC at 760 mmHg
Molecular Formula C12H14N4OS Melting Point 228.8°C
MSDS Chinese USA Flash Point 233.5ºC
Symbol GHS07
GHS07
Signal Word Warning

 Use of Thiochrome


Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors[1][2].

 Names

Name Thiochrome
Synonym More Synonyms

 Thiochrome Biological Activity

Description Thiochrome, a natural oxidation product and metabolite of thiamine, is a selective M4 muscarinic receptor of acetylcholine (ACh) affinity enhancer. Thiochrome has neutral cooperativity with ACh at M1 to M3 receptors[1][2].
Related Catalog
In Vivo Thiochrome can increase the intensity of the reproduction process of the representatives of one-cell organisms worms, crustaceans, insects and fishes[1].
References

[1]. Petrov SA, et al. Administration of Thiamine and Thiochrome Enhanced Reproduction of Chlorella, Drosophila melanogaster, and Danio. J Nutr Sci Vitaminol (Tokyo). 2016;62(1):6-11.

[2]. Lazareno S, et al. Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol Pharmacol. 2004 Jan;65(1):257-66.

 Chemical & Physical Properties

Density 1.49g/cm3
Boiling Point 462.6ºC at 760 mmHg
Melting Point 228.8°C
Molecular Formula C12H14N4OS
Molecular Weight 262.33100
Flash Point 233.5ºC
Exact Mass 262.08900
PSA 91.54000
LogP 0.52090
Index of Refraction 1.752

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles28

More Articles
Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes.

J. Pharmacol. Sci. 125(2) , 157-68, (2014)

The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5'-O-(3-[(35)S]thio) triphosphate ([(35)S]GTPγS) bind...

Salvage of the thiamin pyrimidine moiety by plant TenA proteins lacking an active-site cysteine.

Biochem. J. 463(1) , 145-55, (2014)

The TenA protein family occurs in prokaryotes, plants and fungi; it has two subfamilies, one (TenA_C) having an active-site cysteine, the other (TenA_E) not. TenA_C proteins participate in thiamin sal...

Determination of thiamine and its phosphate esters in rat tissues analyzed as thiochromes on a RP-amide C16 column.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 816(1-2) , 67-72, (2005)

A new reversed-phase chromatographic method is described for the separation and quantification of thiamine (T), thiamine monophosphate (TMP) and diphosphate (TDP) in rat tissues. Sample extraction wit...

 Synonyms

2-(2,7-dimethyl-5H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidin-8-yl)-ethanol
2-(2,7-Dimethyl-5H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidin-8-yl)-aethanol
2-(2,7-dimethyl-5H-thiazolo[3',2':1,2]pyrimido[4,5-d]pyrimidin-8-yl)ethanol
2-{6,12-dimethyl-4-thia-2,7,11,13-tetraazatricyclo[7.4.0.0^{3,7}]trideca-1(13),2,5,9,11-pentaen-5-yl}ethan-1-ol
5H-Pyrimido(4,5-d)thiazolo(3,2-a)pyrimidine-8-ethanol,2,7-dimethyl
T7891_FLUKA
EINECS 202-149-9
2,7-dimethyl-5H-pyrimido[4,5-d]thiazolo[3,2-a]pyrimidine-8-ethanol
2,7-Dimethylthiachromine-8-ethanol
5H-PYRIMIDO(4,5-D)THIAZOLO(3,2-A)PYRIMIDINE-8-ETHANOL, 2,7-DIMETHYL-
THIOCHROME
Thiachrome
MFCD00010519
TETRAKIS(2-ETHYLBUTYL)SILICATE