RET agonist BT44
Modify Date: 2025-09-20 17:22:18
RET agonist BT44 structure
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Common Name | RET agonist BT44 | ||
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| CAS Number | 924759-42-2 | Molecular Weight | 577.595 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H27F4N3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RET agonist BT44RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain. |
| Name | RET agonist BT44 |
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| Description | RET agonist BT44 is a novel, specific RET agonist, promotes RET phosphorylation and selectively activates downstream cascades in the cells expressing GFL receptors.BT44 has no effect on TrkA and TrkB receptors; In GFRα1/RET expressing cells, 10–50 µM of BT44 increased the activity of luciferase reporter by approximately two fold (P<0.0001).BT44 dose-dependently stimulated neurite outgrowth from DRG sensory neurons and its efficacy was comparable to that of ARTN.BT44 alleviated mechanical hypersensitivity in surgery- and diabetes-induced rat models of neuropathic pain. |
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| References | 1. Viisanen H, et al. Mol Pain. 2020 Jan-Dec;16:1744806920950866. 2. Renko JM, et al. J Parkinsons Dis. 2021;11(3):1023-1046. |
| Molecular Formula | C28H27F4N3O4S |
|---|---|
| Molecular Weight | 577.595 |