Bromoacetamido-PEG3-azide

Modify Date: 2024-04-05 13:43:55

Bromoacetamido-PEG3-azide Structure
Bromoacetamido-PEG3-azide structure
Common Name Bromoacetamido-PEG3-azide
CAS Number 940005-81-2 Molecular Weight 339.186
Density N/A Boiling Point N/A
Molecular Formula C10H19BrN4O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bromoacetamido-PEG3-azide


Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-2-bromoacetamide
Synonym More Synonyms

 Bromoacetamido-PEG3-azide Biological Activity

Description Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C10H19BrN4O4
Molecular Weight 339.186
Exact Mass 338.058960
LogP -0.47

 Synonyms

N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-2-bromoacetamide
Acetamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-2-bromo-
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