Desethyl Amiodarone Hydrochloride
Modify Date: 2024-01-08 19:41:23
Desethyl Amiodarone Hydrochloride structure
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Common Name | Desethyl Amiodarone Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 96027-74-6 | Molecular Weight | 653.719 | |
| Density | N/A | Boiling Point | 630.3ºC at 760 mmHg | |
| Molecular Formula | C23H26ClI2NO3 | Melting Point | 176-178ºC | |
| MSDS | N/A | Flash Point | 335ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
Use of Desethyl Amiodarone HydrochlorideDesethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3]. |
| Name | (2-butyl-1-benzofuran-3-yl)-[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]methanone,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Desethylamiodarone hydrochloride (N-desethylamiodarone hydrochloride) is a major active metabolite of Amiodarone. Desethylamiodarone hydrochloride is formed by CYP3A isoenzymes. Amiodarone is an antiarrhythmic agent for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM[1][2][3]. |
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| Related Catalog | |
| References |
| Boiling Point | 630.3ºC at 760 mmHg |
|---|---|
| Melting Point | 176-178ºC |
| Molecular Formula | C23H26ClI2NO3 |
| Molecular Weight | 653.719 |
| Flash Point | 335ºC |
| Exact Mass | 652.969055 |
| PSA | 51.47000 |
| LogP | 7.39680 |
| Storage condition | -20°C Freezer, Under Inert Atmosphere |
| Stability | Moisture Sensitive |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
|
~63%
Desethyl Amioda... CAS#:96027-74-6 |
| Literature: Waldhauser, Katri Maria; Toeroek, Michael; Ha, Huy-Riem; Thomet, Urs; Konrad, Daniel; Brecht, Karin; Follath, Ferenc; Kraehenbuehl, Stephan Journal of Pharmacology and Experimental Therapeutics, 2006 , vol. 319, # 3 p. 1413 - 1423 |
|
~%
Desethyl Amioda... CAS#:96027-74-6 |
| Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 22 p. 5920 - 5922 |
![{4-[2-(benzyl-ethyl-amino)-ethoxy]-3,5-diiodo-phenyl}-(2-butyl-benzofuran-3-yl)-methanone structure](https://www.chemsrc.com/caspic/146/1096359-59-9.png)
| Precursor 3 | |
|---|---|
| DownStream 0 | |
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Single-Cell Analysis: Visualizing Pharmaceutical and Metabolite Uptake in Cells with Label-Free 3D Mass Spectrometry Imaging.
Anal. Chem. 87 , 6696-702, (2015) Detecting metabolites and parent compound within a cell type is now a priority for pharmaceutical development. In this context, three-dimensional secondary ion mass spectrometry (SIMS) imaging was use... |
| Desethylamiodarone hydrochloride |
| desethylamiodarone |
| (2-Butyl-1-benzofuran-3-yl){4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl}methanone hydrochloride (1:1) |
| Methanone, (2-butyl-3-benzofuranyl)[4-[2-(ethylamino)ethoxy]-3,5-diiodophenyl]-, hydrochloride (1:1) |
| mono-N-desethylamiodarone hydrochloride |
| Desethyl Amiodarone Hydrochloride |
| Amiodarone Impurity 2 |