Ciprofloxacin Lactate Soluble

Modify Date: 2025-08-21 18:04:59

Ciprofloxacin Lactate Soluble Structure
Ciprofloxacin Lactate Soluble structure
 Common Name Ciprofloxacin Lactate Soluble
CAS Number 97867-33-9 Molecular Weight 403.404
Density 1.4±0.1 g/cm3 Boiling Point 656.4±55.0 °C at 760 mmHg
Molecular Formula C20H24FN3O6 Melting Point 255-257ºC
MSDS N/A Flash Point 350.8±31.5 °C

 Use of Ciprofloxacin Lactate Soluble


Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].

 Names

Name 1-cyclopropyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid,2-hydroxypropanoic acid
Synonym More Synonyms

 Ciprofloxacin Lactate Soluble Biological Activity

Description Ciprofloxacin (Bay-09867) lactate is a potent, orally active topoisomerase IV inhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and induces apoptosis. Ciprofloxacin lactate is a fluoroquinolone antibiotic, exhibiting potent antibacterial activity[1][2][3][4].
Related Catalog
In Vitro Ciprofloxacin (Bay-09867) lactate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase[1]. Ciprofloxacin (Bay-09867) lactate shows potent activity against Y. pestis and B. anthracis with MIC90 of 0.03 μg/mL and 0.12 μg/mL, respectively[2]. Cell Cycle Analysis[1] Cell Line: Tendon cells Concentration: 5, 10, 20 and 50 μg/mL Incubation Time: 24 hours Result: Decreased the cellularity of tendon cells. Apoptosis Analysis[1] Cell Line: Tendon cells Concentration: 50 μg/mL Incubation Time: 24 hours Result: Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells. Western Blot Analysis[1] Cell Line: Tendon cells Concentration: 50 μg/mL Incubation Time: 0, 6, 12, 17 and 24 hours Result: Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulated the expression of PLK-1 protein.
In Vivo Ciprofloxacin (Bay-09867) lactate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection against Y. pestis in murine model of pneumonic plague[3]. Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall[4]. Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[4]. Animal Model: BALB/c mice[3] Dosage: 30 mg/kg Administration: Intraperitoneal injection; for 24 hours Result: Reduced the lung bacterial load in murine model of pneumonic plague. Animal Model: C57BL/6J mice[4] Dosage: 100 mg/kg Administration: Oral gavage; daily, for 4 weeks Result: Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity. Animal Model: C57BL/6J mice[4] Dosage: 100 mg/kg Administration: Oral gavage; daily, for 4 weeks Result: Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
References

[1]. Tsai WC, et, al. Ciprofloxacin-mediated cell proliferation inhibition and G2/M cell cycle arrest in rat tendon cells. Arthritis Rheum. 2008 Jun;58(6):1657-63.

[2]. Steenbergen J, et, al. In Vitro and In Vivo Activity of Omadacycline against Two Biothreat Pathogens, Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Apr 24;61(5):e02434-16.

[3]. Hamblin KA, et, al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91.

[4]. LeMaire SA, et, al. Effect of Ciprofloxacin on Susceptibility to Aortic Dissection and Rupture in Mice. JAMA Surg. 2018 Sep 1;153(9):e181804.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 656.4±55.0 °C at 760 mmHg
Melting Point 255-257ºC
Molecular Formula C20H24FN3O6
Molecular Weight 403.404
Flash Point 350.8±31.5 °C
Exact Mass 403.154358
PSA 100.87000
LogP 0.04
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.624

 Safety Information

Hazard Codes Xi
HS Code 2933491000

 Customs

HS Code 2933491000
Summary 2933491000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Flunase [inj.]
Cipobacter
Ciproflox [inj.]
Ciprobid Eye Drops
Ciproxin [inj.]
Flociprin [inj.]
Ciproxina [inj.]
Quintor Eye Drops
Ificipro
1-Cyclopropyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinolinecarboxylic 2-hydroxypropanoic anhydride
MFCD01759747
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Ciprofloxacin Lactate Soluble suppliers

Ciprofloxacin Lactate Soluble price

Related Compounds: More...
ciprofloxacin lactate
857213-31-1
Ciprofloxacin Hydrochloride
86483-48-9
Ciprofloxacin-d8
1130050-35-9
6-[(2-aminoethyl)amino]-7-chloro-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride
528851-30-1
Ciprofloxacin Piperazinyl-N4-sulfate
105093-21-8
Ciprofloxacin Hydrochloride
102-92-1
Ciprofloxacin EP IMpurity D
133210-96-5
Ciprofloxacin
85721-33-1
Ciprofloxacin N-Oxide
860033-22-3
8-cyclohexyl-2-(1H-1,2,4-triazol-5-yl)-3,4,4a,5,5a,6,7,9a,10,10a-decahydropyrido[4,3-b][1,6]naphthyridine-1,9-dione
1158237-01-4
8-cycloheptyl-2-(1H-1,2,4-triazol-5-yl)-3,4,4a,5,5a,6,7,9a,10,10a-decahydropyrido[4,3-b][1,6]naphthyridine-1,9-dione
1158430-90-0
8-pyridin-2-yl-2-(1H-1,2,4-triazol-5-yl)-3,4,4a,5,5a,6,7,9a,10,10a-decahydropyrido[4,3-b][1,6]naphthyridine-1,9-dione
1158758-41-8
8-pyridin-4-yl-2-(1H-1,2,4-triazol-5-yl)-3,4,4a,5,5a,6,7,9a,10,10a-decahydropyrido[4,3-b][1,6]naphthyridine-1,9-dione
1158338-67-0
2-(4-methylpiperazin-1-yl)-5-pyridin-2-yl-2,3,4a,5,6,7,8,8a-octahydro-1H-pyrido[2,3-d]pyrimidin-4-one
1158593-31-7
2-morpholin-4-yl-5-pyridin-3-yl-2,3,4a,5,6,7,8,8a-octahydro-1H-pyrido[2,3-d]pyrimidin-4-one
1158486-56-6
5-pyridin-3-yl-2-pyrrolidin-1-yl-2,3,4a,5,6,7,8,8a-octahydro-1H-pyrido[2,3-d]pyrimidin-4-one
1158618-93-9
2-anilino-5-pyridin-3-yl-2,3,4a,5,6,7,8,8a-octahydro-1H-pyrido[2,3-d]pyrimidin-4-one
1158561-99-9
2-(4-phenoxyanilino)-5-pyridin-3-yl-2,3,4a,5,6,7,8,8a-octahydro-1H-pyrido[2,3-d]pyrimidin-4-one
1158342-90-5
2-(2-chloroanilino)-5-pyridin-3-yl-2,3,4a,5,6,7,8,8a-octahydro-1H-pyrido[2,3-d]pyrimidin-4-one
1158276-53-9
Chemsrc provides Ciprofloxacin Lactate Soluble(CAS#:97867-33-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ciprofloxacin Lactate Soluble are included as well.>> amp version: Ciprofloxacin Lactate Soluble

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved