L-651,582

Modify Date: 2025-08-23 17:57:16

L-651,582 Structure
L-651,582 structure
Common Name L-651,582
CAS Number 99519-84-3 Molecular Weight 424.67
Density 1.65g/cm3 Boiling Point 685.5ºC at 760 mmHg
Molecular Formula C17H12Cl3N5O2 Melting Point N/A
MSDS Chinese USA Flash Point 368.3ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of L-651,582


Carboxyamidotriazole (L 651582; CAI) is a blocker of non-voltage dependent calcium channel[1]. Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic anti-tumor drug, which also shows anti-inflammatory activity[2].

 Names

Name 5-amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]triazole-4-carboxamide
Synonym More Synonyms

 L-651,582 Biological Activity

Description Carboxyamidotriazole (L 651582; CAI) is a blocker of non-voltage dependent calcium channel[1]. Carboxyamidotriazole (L 651582; CAI) is a non-cytotoxic anti-tumor drug, which also shows anti-inflammatory activity[2].
Related Catalog
Target

Calcium channel[1]

References

[1]. Chen C, et al. Carboxyamidotriazole Synergizes with Sorafenib to Combat Non-Small Cell Lung Cancer through Inhibition of NANOG and Aggravation of Apoptosis. J Pharmacol Exp Ther. 2017 Aug;362(2):219-229.

[2]. Hussain MM, et al. J Clin Oncol. 2003 Dec 1;21(23):4356-63.

 Chemical & Physical Properties

Density 1.65g/cm3
Boiling Point 685.5ºC at 760 mmHg
Molecular Formula C17H12Cl3N5O2
Molecular Weight 424.67
Flash Point 368.3ºC
Exact Mass 423.00600
PSA 116.89000
LogP 4.48020
Index of Refraction 1.73
InChIKey WNRZHQBJSXRYJK-UHFFFAOYSA-N
SMILES NC(=O)c1nnn(Cc2cc(Cl)c(C(=O)c3ccc(Cl)cc3)c(Cl)c2)c1N

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Hazard Codes T+
RIDADR UN 2811 6.1 / PGIII

 Synthetic Route

 Articles37

More Articles
Comparison of the applicability of mass spectrometer ion sources using a polarity- molecular weight scattergram with a 600 sample in-house chemical library.

Eur. J. Mass Spectrom. (Chichester, Eng.) 21 , 91-6, (2015)

To provide a practical guideline for the selection of a mass spectrometer ion source, we compared the applicability of three types of ion source: direct analysis in real time (DART), electrospray ioni...

Differentially expressed and activated proteins associated with non small cell lung cancer tissues.

Respir. Res. 16 , 74, (2015)

Lung cancer is a leading cause of mortality. The most common cancer subtype, non small cell lung cancer (NSCLC), accounts for 85-90% all cases and is mainly caused by environmental and genetic factors...

Intergenerational cultural conflict, mental health, and educational outcomes among Asian and Latino/a Americans: Qualitative and meta-analytic review.

Psychol. Bull. 141(2) , 404-46, (2015)

Among immigrant Asian and Latino groups, the contrast between collectivism in traditional heritage and individualism in the mainstream American cultures presents unique challenges for their family rel...

 Synonyms

4-CAI
CAI
Carboxyamido-triazole
Carboxyamidotriazole
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