TPB15

Modify Date: 2024-01-21 09:37:35

TPB15 structure	Common Name	TPB15
	CAS Number	2170347-69-8	Molecular Weight	453.11
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₉Cl₄N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TPB15

TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].

Name	TPB15

Description	TPB15 is an orally active and potent Hh (Hedgehog) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 (Gli1). TPB15 shows good anti-tumor activity with low toxicity[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Signaling Pathways >> Stem Cell/Wnt >> Gli Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Hedgehog
References	[1]. Tian N, et al. Discovery of [1,2,4]triazolo[4,3-a]pyridines as potent Smoothened inhibitors targeting the Hedgehog pathway with improved antitumor activity in vivo. Bioorg Med Chem. 2020 Aug 15;28(16):115584.

Molecular Formula	C₁₈H₉Cl₄N₅O
Molecular Weight	453.11

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TPB15

Use of TPB15

Names

TPB15 Biological Activity

Chemical & Physical Properties