4-Androsten-4-ol-3,17-dione acetate

Modify Date: 2024-01-02 12:19:29

4-Androsten-4-ol-3,17-dione acetate Structure
4-Androsten-4-ol-3,17-dione acetate structure
 Common Name 4-Androsten-4-ol-3,17-dione acetate
CAS Number 61630-32-8 Molecular Weight 344.44500
Density 1.18g/cm3 Boiling Point 501.2ºC at 760 mmHg
Molecular Formula C21H28O4 Melting Point N/A
MSDS Chinese USA Flash Point 219.2ºC

 Names

Name 4-Androsten-4-ol-3,17-dione acetate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.18g/cm3
Boiling Point 501.2ºC at 760 mmHg
Molecular Formula C21H28O4
Molecular Weight 344.44500
Flash Point 219.2ºC
Exact Mass 344.19900
PSA 60.44000
LogP 3.97820
Index of Refraction 1.548

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BV8153000
CHEMICAL NAME :
Androst-4-ene-3,17-dione, 4-hydroxy-, acetate (ester)
CAS REGISTRY NUMBER :
61630-32-8
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H28-O4
MOLECULAR WEIGHT :
344.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
300 mg/kg
SEX/DURATION :
female 2-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 18,365,1978
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
DOSE :
375 mg/kg
SEX/DURATION :
female 18 day(s) pre-mating female 1-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 18,365,1978

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
RTECS BV8153000

 Synthetic Route

Formestane structure

Formestane

CAS#:566-48-3
Acetyl chloride structure

Acetyl chloride

CAS#:75-36-5

~97%

4-Androsten-4-ol-3,17-dione acetate Structure

4-Androsten-4-o...

CAS#:61630-32-8
Literature: Andrade; Paixao; De Almeida; Fernandes Roleira; Tavares Da Silva Acta Crystallographica Section C: Crystal Structure Communications, 2007 , vol. 63, # 6 p. o330-o331
Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7
Formestane structure

Formestane

CAS#:566-48-3

~66%

4-Androsten-4-ol-3,17-dione acetate Structure

4-Androsten-4-o...

CAS#:61630-32-8
Literature: Marsh, David A.; Brodie, Harry J.; Garrett, Wesley; Tsai-Morris, Chon-Hwa; Brodie, Angela M. H. Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 788 - 795
4,5-epoxyandrostane-3,17-dione structure

4,5-epoxyandros...

CAS#:77057-73-9

~%

4-Androsten-4-ol-3,17-dione acetate Structure

4-Androsten-4-o...

CAS#:61630-32-8
Literature: Mann, John; Pietrzak, Barbara Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2681 - 2685
Formestane structure

Formestane

CAS#:566-48-3
Acetylsalicyloyl chloride structure

Acetylsalicyloy...

CAS#:5538-51-2

~%

4-(O-acetylsalicyloxy)androst-4-en-3,17-dione structure

4-(O-acetylsali...

CAS#:1373116-44-9
4-Androsten-4-ol-3,17-dione acetate Structure

4-Androsten-4-o...

CAS#:61630-32-8
Literature: Varela, Carla; Tavares Da Silva, Elisiario J.; Amaral, Cristina; Correia Da Silva, Georgina; Baptista, Teresa; Alcaro, Stefano; Costa, Giosue; Carvalho, Rui A.; Teixeira, Natercia A. A.; Roleira, Fernanda M. F. Journal of Medicinal Chemistry, 2012 , vol. 55, # 8 p. 3992 - 4002
Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7
5-α-fluoro-4α-hydroxyandrostane-3,17-dione structure

5-α-fluoro-4α-h...

CAS#:66880-12-4

~%

4-Androsten-4-ol-3,17-dione acetate Structure

4-Androsten-4-o...

CAS#:61630-32-8
Literature: Mann, John; Pietrzak, Barbara Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 11 p. 2681 - 2685

 Articles14

More Articles
Aromatase inhibitors and the treatment of breast cancer.

J. Steroid Biochem. 24 , 91, (1986)

Inhibition of aromatase to reduce estrogen production by peripheral and ovarian tissue could be a useful approach to treating hormone-dependent breast cancer. Several C19, 17 keto steroids have been i...
Inhibition of estrogen biosynthesis and regression of mammary tumors by aromatase inhibitors.

Adv. Exp. Med. Biol. 138 , 179-90, (1981)
Overview of recent development of aromatase inhibitors.

Cancer Res. 42(8 Suppl) , 3312s-3314s, (1982)

Since the first publication in 1973 concerning aromatase inhibitors, several effective compounds have been reported by a number of investigators. Our studies with 4-hydroxyandrostene-3,17-dione, 4-ace...

 Synonyms

[(8R,9S,10R,13S,14S)-10,13-dimethyl-3,17-dioxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-4-yl] acetate
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